Attempt to rescue discarded human liver grafts by end ischemic hypothermic oxygenated machine perfusion

K Vekemans, J Van Pelt, M Komuta, T Wylin… - Transplantation …, 2011 - Elsevier
In a porcine liver transplant model, a brief period of oxygenated hypothermic machine
perfusion (HMP) at the end of simple cold storage (SCS) has been shown to improve the …

Technique of subnormothermic ex vivo liver perfusion for the storage, assessment, and repair of marginal liver grafts

JM Knaak, VN Spetzler, N Goldaracena… - JoVE (Journal of …, 2014 - jove.com
The success of liver transplantation has resulted in a dramatic organ shortage. In most
transplant regions 20-30% of patients on the waiting list for liver transplantation die without …

Normothermic perfusion: a new paradigm for organ preservation

J Brockmann, S Reddy, C Coussios, D Pigott… - Annals of …, 2009 - journals.lww.com
Objective: Transplantation of organs retrieved after cardiac arrest could increase the donor
organ supply. However, the combination of warm ischemia and cold preservation is highly …

Liver and kidney preservation by perfusion

SD St Peter, CJ Imber, PJ Friend - The Lancet, 2002 - thelancet.com
The clinical boundaries of transplantation have been set in an era of simple cold storage.
Research in organ preservation has led to the development of flush solutions that buffer the …

[HTML][HTML] Liver graft preservation methods during cold ischemia phase and normothermic machine perfusion

KY Tchilikidi - World Journal of Gastrointestinal Surgery, 2019 - ncbi.nlm.nih.gov
The growing demand for donor organs requires measures to expand donor pool. Those
include extended criteria donors, such as elderly people, steatotic livers, donation after …

Hypothermic oxygenated liver perfusion: basic mechanisms and clinical application

A Schlegel, P Kron, P Dutkowski - Current transplantation reports, 2015 - Springer
Dynamic preservation strategies such as hypothermic machine perfusion are increasingly
discussed to improve liver graft quality before transplantation. This review summarizes …

The first case of ischemia-free organ transplantation in humans: a proof of concept

OB van Leeuwen, R Ubbink… - American Journal of …, 2018 - amjtransplant.org
With great interest we have read the article by Xiaoshun He and colleagues regarding their
first patient who underwent successful ischemia-free organ transplantation (IFOT). 1 This …

HETEROGENEOUS FLOW PATTERNS DURING HYPOTHERMIC MACHINE PERFUSION PRESERVATION OF LIVERS1

CY Lee, JX Zhang, H DeSilva, RN Coger… - …, 2000 - journals.lww.com
Background. Hypothermic machine perfusion preservation (MPP) has the potential to relieve
the current donor shortage problem by providing superior preserved tissue and viable non …

Normothermic perfusion in the assessment and preservation of declined livers before transplantation: hyperoxia and vasoplegia—important lessons from the first 12 …

CJE Watson, V Kosmoliaptsis, LV Randle… - …, 2017 - journals.lww.com
Background A program of normothermic ex situ liver perfusion (NESLiP) was developed to
facilitate better assessment and use of marginal livers, while minimizing cold ischemia …

Transplanting marginal organs in the era of modern machine perfusion and advanced organ monitoring

T Resch, B Cardini, R Oberhuber… - Frontiers in …, 2020 - frontiersin.org
Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …