Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: focus on ion channels
F Veit, O Pak, RP Brandes… - Antioxidants & redox …, 2015 - liebertpub.com
Significance: An acute lack of oxygen in the lung causes hypoxic pulmonary
vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a …
vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a …
ROS-Dependent Signaling Mechanisms for Hypoxic Ca2+ Responses in Pulmonary Artery Myocytes
YX Wang, YM Zheng - Antioxidants & redox signaling, 2010 - liebertpub.com
Hypoxic exposure causes pulmonary vasoconstriction, which serves as a critical physiologic
process that ensures regional alveolar ventilation and pulmonary perfusion in the lungs, but …
process that ensures regional alveolar ventilation and pulmonary perfusion in the lungs, but …
Hypoxia-induced changes in pulmonary and systemic vascular resistance: where is the O2 sensor?
GB Waypa, PT Schumacker - Respiratory physiology & neurobiology, 2010 - Elsevier
Pulmonary arteries (PA) constrict in response to alveolar hypoxia, whereas systemic arteries
(SA) undergo dilation. These physiological responses reflect the need to improve gas …
(SA) undergo dilation. These physiological responses reflect the need to improve gas …
Regulation of ion transport by oxidants
CA Downs, MN Helms - American Journal of Physiology …, 2013 - journals.physiology.org
Ion channels perform a variety of cellular functions in lung epithelia. Oxidant-and antioxidant-
mediated mechanisms (that is, redox regulation) of ion channels are areas of intense …
mediated mechanisms (that is, redox regulation) of ion channels are areas of intense …
Reactive oxygen species signaling in pulmonary vascular smooth muscle
In recent years, it has become evident that reactive oxygen species (ROS) play a critical role
in the regulation of several physiological and pathophysiological processes. Herein we …
in the regulation of several physiological and pathophysiological processes. Herein we …
Prolonged hypoxia increases ROS signaling and RhoA activation in pulmonary artery smooth muscle and endothelial cells
AY Chi, GB Waypa, PT Mungai… - Antioxidants & redox …, 2010 - liebertpub.com
Phase I of the hypoxic pulmonary vasoconstriction (HPV) response begins upon transition to
hypoxia and involves an increase in cytosolic calcium ([Ca2+] i). Phase II develops during …
hypoxia and involves an increase in cytosolic calcium ([Ca2+] i). Phase II develops during …
Redox regulation of ion channels in the pulmonary circulation
A Olschewski, EK Weir - Antioxidants & redox signaling, 2015 - liebertpub.com
Significance: The pulmonary circulation is a low-pressure, low-resistance, highly compliant
vasculature. In contrast to the systemic circulation, it is not primarily regulated by a central …
vasculature. In contrast to the systemic circulation, it is not primarily regulated by a central …
Hypoxia induces Kv channel current inhibition by increased NADPH oxidase-derived reactive oxygen species
M Mittal, XQ Gu, O Pak, ME Pamenter, D Haag… - Free Radical Biology …, 2012 - Elsevier
There is current discussion whether reactive oxygen species are up-or downregulated in the
pulmonary circulation during hypoxia, from which sources (ie, mitochondria or NADPH …
pulmonary circulation during hypoxia, from which sources (ie, mitochondria or NADPH …
Subcellular Redox Signaling
L Zhu, Y Lu, J Zhang, Q Hu - … Vasculature Redox Signaling in Health and …, 2017 - Springer
Oxidative and antioxidative system of cells and tissues maintains a balanced state under
physiological conditions. A disruption in this balance of redox status has been associated …
physiological conditions. A disruption in this balance of redox status has been associated …
Oxidant signaling in lung cells
RS Frey, AB Malik - American Journal of Physiology-Lung …, 2004 - journals.physiology.org
THIS ISSUE of the American Journal of Physiology-Lung Cellular and Molecular Physiology
features five articles that provide new insights into the mechanisms and cellular pathways …
features five articles that provide new insights into the mechanisms and cellular pathways …