Significance: An acute lack of oxygen in the lung causes hypoxic pulmonary
vasoconstriction, which optimizes gas exchange. In contrast, chronic hypoxia triggers a …

Hypoxic exposure causes pulmonary vasoconstriction, which serves as a critical physiologic
process that ensures regional alveolar ventilation and pulmonary perfusion in the lungs, but …

Pulmonary arteries (PA) constrict in response to alveolar hypoxia, whereas systemic arteries
(SA) undergo dilation. These physiological responses reflect the need to improve gas …

Ion channels perform a variety of cellular functions in lung epithelia. Oxidant-and antioxidant-
mediated mechanisms (that is, redox regulation) of ion channels are areas of intense …

In recent years, it has become evident that reactive oxygen species (ROS) play a critical role
in the regulation of several physiological and pathophysiological processes. Herein we …

Phase I of the hypoxic pulmonary vasoconstriction (HPV) response begins upon transition to
hypoxia and involves an increase in cytosolic calcium ([Ca2+] i). Phase II develops during …

Significance: The pulmonary circulation is a low-pressure, low-resistance, highly compliant
vasculature. In contrast to the systemic circulation, it is not primarily regulated by a central …

There is current discussion whether reactive oxygen species are up-or downregulated in the
pulmonary circulation during hypoxia, from which sources (ie, mitochondria or NADPH …

Oxidative and antioxidative system of cells and tissues maintains a balanced state under
physiological conditions. A disruption in this balance of redox status has been associated …

THIS ISSUE of the American Journal of Physiology-Lung Cellular and Molecular Physiology
features five articles that provide new insights into the mechanisms and cellular pathways …