Engineering mesenchymal stem cells to improve their exosome efficacy and yield for cell-free therapy

J Phan, P Kumar, D Hao, K Gao… - Journal of extracellular …, 2018 - Taylor & Francis
Through traditional medicine, there were diseases and disorders that previously remained
untreated or were simply thought to be incurable. Since the discovery of mesenchymal stem …

Challenges and strategies: scalable and efficient production of mesenchymal stem cells-derived exosomes for cell-free therapy

W Pan, H Chen, A Wang, F Wang, X Zhang - Life sciences, 2023 - Elsevier
Exosomes are small membrane vesicles secreted by most cell types, and widely exist in cell
supernatants and various body fluids. They can transmit numerous bioactive elements, such …

Preconditioning and Engineering Strategies for Improving the Efficacy of Mesenchymal Stem Cell‐Derived Exosomes in Cell‐Free Therapy

S Chen, F Sun, H Qian, W Xu, J Jiang - Stem cells international, 2022 - Wiley Online Library
Mesenchymal stem cells (MSCs) have been widely applied to regenerative medicine owing
to their multiple differentiation, self‐renewal, and immunomodulatory abilities. Exosomes are …

Exosome: a novel and safer therapeutic refinement of mesenchymal stem cell

RWY Yeo, RC Lai, KH Tan… - Exosomes and …, 2013 - journals.sagepub.com
Mesenchymal stem cell (MSC) has just been approved as the first “off-the-shelf” stem cell
pharmaceutical drug with an anticipation of more approvals following completion of …

Mesenchymal stem cell-derived exosomes for clinical use

M Mendt, K Rezvani, E Shpall - Bone marrow transplantation, 2019 - nature.com
Mesenchymal stem/stromal cells (MSCs) are commonly used as a source of cellular therapy
due to their strong immunosuppressive and regenerative effects. One of the key …

The extracellular vesicles‐derived from mesenchymal stromal cells: A new therapeutic option in regenerative medicine

VT Nooshabadi, S Mardpour… - Journal of cellular …, 2018 - Wiley Online Library
Mesenchymal stem cells (MSCs) are adult multipotent cells that due to their ability to homing
to damaged tissues and differentiate into specialized cells, are remarkable cells in the field …

[HTML][HTML] Mesenchymal stem cell-derived exosomes: Toward cell-free therapeutic strategies in regenerative medicine

ZJ Ma, JJ Yang, YB Lu, ZY Liu… - World journal of stem …, 2020 - ncbi.nlm.nih.gov
Mesenchymal stem cells (MSCs) are multipotent stem cells with marked potential for
regenerative medicine because of their strong immunosuppressive and regenerative …

Mesenchymal stem cell-derived extracellular vesicles: opportunities and challenges for clinical translation

M Maumus, P Rozier, J Boulestreau… - … in Bioengineering and …, 2020 - frontiersin.org
Extracellular vesicles (EVs), including exosomes and microvesicles, derived from
mesenchymal stem/stromal cells (MSCs) exert similar effects as their parental cells, and are …

NANOmetric BIO-banked MSC-derived exosome (NANOBIOME) as a novel approach to regenerative medicine

B Codispoti, M Marrelli, F Paduano… - Journal of Clinical …, 2018 - mdpi.com
Mesenchymal stem cells (MSCs) are well known for their great potential in clinical
applications. In fact, MSCs can differentiate into several cell lineages and show paracrine …

Mesenchymal stem/stromal cell-derived exosomes in regenerative medicine and cancer; overview of development, challenges, and opportunities

A Hassanzadeh, HS Rahman, A Markov… - Stem cell research & …, 2021 - Springer
Recently, mesenchymal stem/stromal cells (MSCs) and their widespread biomedical
applications have attracted great consideration from the scientific community around the …