Engagement of phospholipid scramblase 1 in activated cells: implication for phosphatidylserine externalization and exocytosis

D Smrz, P Lebduska, J Korb, P Dráber - Journal of Biological Chemistry, 2008 - ASBMB
Phosphatidylserine (PS) in quiescent cells is predominantly confined to the inner leaflet of
the plasma membrane. Externalization of PS is a marker of apoptosis, exocytosis, and some …

Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane

T Wiedmer, J Zhao, M Nanjundan, PJ Sims - Biochemistry, 2003 - ACS Publications
Phospholipid scramblase 1 (PLSCR1) is a Ca2+-binding, endofacial plasma membrane
protein thought to contribute to the transbilayer movement of phosphatidylserine and other …

Plasma membrane phospholipid scramblase 1 promotes EGF-dependent activation of c-Src through the epidermal growth factor receptor

M Nanjundan, J Sun, J Zhao, Q Zhou, PJ Sims… - Journal of Biological …, 2003 - ASBMB
Phospholipid scramblase (PLSCR1) is a multiply palmitoylated, calcium-binding endofacial
membrane protein proposed to mediate transbilayer movement of plasma membrane …

Plasma membrane phospholipid scramblase 1 is enriched in lipid rafts and interacts with the epidermal growth factor receptor

J Sun, M Nanjundan, LJ Pike, T Wiedmer, PJ Sims - Biochemistry, 2002 - ACS Publications
We have identified physical and functional interactions between the epidermal growth factor
(EGF) receptor and phospholipid scramblase 1 (PLSCR1), an endofacial plasma membrane …

Normal hemostasis but defective hematopoietic response to growth factors in mice deficient in phospholipid scramblase 1

Q Zhou, J Zhao, T Wiedmer… - Blood, The Journal of the …, 2002 - ashpublications.org
Phospholipid scramblase 1 (PLSCR1) is an endofacial plasma membrane protein proposed
to participate in transbilayer movement of phosphatidylserine and other phospholipids. In …

Phospholipid scramblase 1 modulates FcR-mediated phagocytosis in differentiated macrophages

C Herate, G Ramdani, NJ Grant, S Marion, S Gasman… - PLoS …, 2016 - journals.plos.org
Phospholipid Scramblase 1 (PLSCR1) was initially characterized as a type II
transmembrane protein involved in bilayer movements of phospholipids across the plasma …

Phospholipid scramblase 1: a protein with multiple functions via multiple molecular interactors

J Dal Col, MJ Lamberti, A Nigro, V Casolaro… - Cell Communication and …, 2022 - Springer
Abstract Phospholipid scramblase 1 (PLSCR1) is the most studied protein of the scramblase
family. Originally, it was identified as a membrane protein involved in maintaining plasma …

c-Abl tyrosine kinase binds and phosphorylates phospholipid scramblase 1

J Sun, J Zhao, MA Schwartz, JYJ Wang… - Journal of Biological …, 2001 - ASBMB
Phospholipid scramblase 1 (PLSCR1) is a plasma membrane protein that has been
proposed to play a role in the transbilayer movement of plasma membrane phospholipids …

Phospholipid scramblases: an overview

SK Sahu, SN Gummadi, N Manoj… - Archives of biochemistry …, 2007 - Elsevier
Phospholipid scramblases are a group of homologous proteins that are conserved in all
eukaryotic organisms. They are believed to be involved in destroying plasma membrane …

Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cδ

SC Frasch, PM Henson, JM Kailey, DA Richter… - Journal of Biological …, 2000 - ASBMB
Phospholipid scramblase induces nonspecific bidirectional movement of phospholipids
across the membrane during cell activation and has been proposed to mediate the …