Multi-targeted protection of acetaminophen-induced hepatotoxicity in mice by tannic acid

J Zhang, Q Song, X Han, Y Zhang, Y Zhang… - International …, 2017 - Elsevier
Tannic acid (TA) is the polyphenol that has beneficial health effects against oxidative stress.
However, the hepatoprotective effects of TA are still relatively unknown. In the present study …

Prospective application of tannic acid in acetaminophen (APAP)-induced acute liver failure

YH Lin, YC Lin, YT Hou - International Journal of Molecular Sciences, 2023 - mdpi.com
This study investigated the effect of tannic acid (TA), a natural plant-derived polyphenol, on
hepatocyte viability and function, focusing on both hepatoprotective and hepatocurative …

Protective effects of nicotinamide against acetaminophen-induced acute liver injury

Y Shi, L Zhang, R Jiang, W Chen, W Zheng… - International …, 2012 - Elsevier
Nicotinamide (NAM), the amide form of vitamin B3, is involved in a wide range of biological
processes. Recent evidence revealed the anti-inflammatory and anti-oxidant properties of …

Salvianolic acid C against acetaminophen‐induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the Keap1/Nrf2 …

CT Wu, JS Deng, WC Huang, PC Shieh… - Oxidative Medicine …, 2019 - Wiley Online Library
Acetaminophen (APAP) overdose is one of the most common causes of drug‐induced acute
liver failure in humans. To investigate the hepatoprotective effect of salvianolic acid C (SAC) …

Apigenin alleviated acetaminophen‐induced hepatotoxicity in low protein‐fed rats: Targeting oxidative stress, STAT3, and apoptosis signals

WR Mohamed, AS Kotb… - … of biochemical and …, 2020 - Wiley Online Library
Apigenin (API) is a natural flavonoid abundant in fruits and vegetables. The present study
was undertaken to evaluate the effect of protein malnutrition (PMN) on acetaminophen …

Capsaicin alleviates acetaminophen-induced acute liver injury in mice

X Zhan, J Zhang, H Chen, L Liu, Y Zhou, T Zheng… - Clinical …, 2020 - Elsevier
Overdose of N-acetyl-para-aminophenol (APAP) can induce acute liver injury (ALI). We
evaluated the potential protective effect of 8-methyl-N-geranyl-6-nonamide (capsaicin …

Astaxanthin pretreatment attenuates acetaminophen-induced liver injury in mice

J Zhang, S Zhang, J Bi, J Gu, Y Deng, C Liu - International …, 2017 - Elsevier
Background Acetaminophen (APAP) is a conventional drug widely used in the clinic
because of its antipyretic-analgesic effects. However, accidental or intentional APAP …

Curative Effects of Thiacremonone against Acetaminophen‐Induced Acute Hepatic Failure via Inhibition of Proinflammatory Cytokines Production and Infiltration of …

YR Kim, NJ Lee, JO Ban, HS Yoo… - Evidence‐Based …, 2013 - Wiley Online Library
High doses of acetaminophen (APAP; N‐acetyl‐p‐aminophenol) cause severe
hepatotoxicity after metabolic activation by cytochrome P450 2E1. This study was …

Extract of Triticum aestivum Sprouts Suppresses Acetaminophen-Induced Hepatotoxicity in Mice by Inhibiting Oxidative Stress

JY Lim, DH Yun, JH Lee, YB Kwon, YM Lee, DH Lee… - Molecules, 2021 - mdpi.com
Wheat (Triticum aestivum L.) is the oldest known food crop, and many studies have reported
that wheat shoots (ie, wheatgrass) possess anti-cancer, anti-inflammatory, and antioxidant …

The protective effects of carvacrol and thymol against paracetamol–induced toxicity on human hepatocellular carcinoma cell lines (HepG2)

SS Palabiyik, E Karakus, Z Halici… - Human & …, 2016 - journals.sagepub.com
Acetaminophen (APAP) overdose could induce liver damage and lead to acute liver failure.
The treatment of APAP overdoses could be improved by new therapeutic strategies. Thymus …