[HTML][HTML] Comparison of functional assays used in the clinical development of a placental malaria vaccine
C Pehrson, KK Heno, Y Adams, M Resende… - Vaccine, 2017 - Elsevier
Background Malaria in pregnancy is associated with significant morbidity in pregnant
women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express …
women and their offspring. Plasmodium falciparum infected erythrocytes (IE) express …
[HTML][HTML] Down-selection of the VAR2CSA DBL1-2 expressed in E. coli as a lead antigen for placental malaria vaccine development
A Chêne, S Gangnard, C Dechavanne, S Dechavanne… - NPJ vaccines, 2018 - nature.com
Over 50 million women are exposed to the risk of malaria during pregnancy every year.
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
Malaria during pregnancy is a leading global cause of maternal morbidity and adverse …
[HTML][HTML] Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays
M Hommel, JA Chan, AJ Umbers, C Langer… - Parasites & vectors, 2018 - Springer
Background Malaria in pregnancy is a major cause of poor maternal and infant health, and
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …
is associated with the sequestration of P. falciparum-infected erythrocytes (IE) in the …
[HTML][HTML] Differential Induction of Functional IgG Using the Plasmodium falciparum Placental Malaria Vaccine Candidate VAR2CSA
VV Pinto, SB Ditlev, KE Jensen, M Resende… - PloS one, 2011 - journals.plos.org
Background In Plasmodium falciparum malaria endemic areas placental malaria (PM) is an
important complication of malaria. The recurrence of malaria in primigravidae women …
important complication of malaria. The recurrence of malaria in primigravidae women …
[HTML][HTML] Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
[HTML][HTML] Progress towards vaccines to protect pregnant women from malaria
SJ Rogerson, EH Aitken - EBioMedicine, 2019 - thelancet.com
Pregnant women are particularly susceptible to infection with the malaria parasite
Plasmodium falciparum, with severe consequences for maternal and offspring health …
Plasmodium falciparum, with severe consequences for maternal and offspring health …
[HTML][HTML] Progress and insights toward an effective placental malaria vaccine
B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …
malaria is progressively acquired during childhood and adults are usually protected against …
[HTML][HTML] Var2CSA DBL6-epsilon domain expressed in HEK293 induces limited cross-reactive and blocking antibodies to CSA binding parasites
P Fernandez, NK Viebig, S Dechavanne, C Lépolard… - Malaria Journal, 2008 - Springer
Background Pregnancy-associated malaria (PAM) is a serious consequence of Plasmodium
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
falciparum-infected erythrocytes sequestration in the placenta through the adhesion to the …
[HTML][HTML] Protective antibodies against placental malaria and poor outcomes during pregnancy, Benin
NT Ndam, L Denoeud-Ndam… - Emerging infectious …, 2015 - ncbi.nlm.nih.gov
Placental malaria is caused by Plasmodium falciparum–infected erythrocytes that bind to
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …
placental tissue. Binding is mediated by VAR2CSA, a parasite antigen coded by the var …
Functional antibodies against placental malaria parasites are variant dependent and differ by geographic region
During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) accumulate in the
intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit …
intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit …