Reactive oxygen species-mediated cardiac-reperfusion injury: mechanisms and therapies

F Bagheri, V Khori, AM Alizadeh, S Khalighfard… - Life Sciences, 2016 - Elsevier
Reperfusion injury is an inherent response to the restoration of blood flow after ischemia. It is
a complex process involving numerous mechanisms occurring in the intracellular and …

The cellular and molecular origin of reactive oxygen species generation during myocardial ischemia and reperfusion

K Raedschelders, DM Ansley, DDY Chen - Pharmacology & therapeutics, 2012 - Elsevier
Myocardial ischemia-reperfusion injury is an important cause of impaired heart function in
the early postoperative period subsequent to cardiac surgery. Reactive oxygen species …

New concepts in reactive oxygen species and cardiovascular reperfusion physiology

LB Becker - Cardiovascular research, 2004 - academic.oup.com
Increasingly complex behavior of free radicals and reactive oxygen species (ROS) are noted
within biological systems. Classically free radicals and ROS were considered injurious …

Ischemia‐reperfusion and cardioprotection: a delicate balance between reactive oxygen species generation and redox homeostasis

SK Goswami, N Maulik, DK Das - Annals of medicine, 2007 - Taylor & Francis
Ischemia‐reperfusion injury of the myocardium has long been a subject of intense research.
Cardiac preconditioning, an associated phenomenon, has also been critically investigated …

Reactive oxygen species in myocardial reperfusion injury: from physiopathology to therapeutic approaches

V Braunersreuther, V Jaquet - Current pharmaceutical …, 2012 - ingentaconnect.com
Myocardial ischemia is a major cause of morbidity and mortality in the world. Although
restoration of blood flow after prolonged ischemia is essential for cardiomyocytes salvation …

Molecular characterization of reactive oxygen species in myocardial ischemia‐reperfusion injury

T Zhou, CC Chuang, L Zuo - BioMed research international, 2015 - Wiley Online Library
Myocardial ischemia‐reperfusion (I/R) injury is experienced by individuals suffering from
cardiovascular diseases such as coronary heart diseases and subsequently undergoing …

Oxidative stress and cardiac disease

DJ Lefer, DN Granger - The American journal of medicine, 2000 - Elsevier
Reactive oxygen species (ROS) are formed at an accelerated rate in postischemic
myocardium. Cardiac myocytes, endothelial cells, and infiltrating neutrophils contribute to …

[HTML][HTML] Health position paper and redox perspectives on reactive oxygen species as signals and targets of cardioprotection

G Heusch, I Andreadou, R Bell, E Bertero, HE Botker… - Redox Biology, 2023 - Elsevier
The present review summarizes the beneficial and detrimental roles of reactive oxygen
species in myocardial ischemia/reperfusion injury and cardioprotection. In the first part, the …

Cellular crosstalk in cardioprotection: where and when do reactive oxygen species play a role?

T Martins-Marques, A Rodriguez-Sinovas… - Free Radical Biology and …, 2021 - Elsevier
A well-balanced intercellular communication between the different cells within the heart is
vital for the maintenance of cardiac homeostasis and function. Despite remarkable advances …

Role of oxygen in postischemic myocardial injury

VK Kutala, M Khan, MG Angelos… - Antioxidants & Redox …, 2007 - liebertpub.com
Myocardial function is dependent on a constant supply of oxygen from the coronary
circulation. A reduction of oxygen supply due to coronary obstruction results in myocardial …