Abstract The antitumor drug navelbine (5′-noranhydrovinblastine) was converted into a
reactive acid azide and covalently coupled to free amino groups of bovine serum albumin …

Eleven patients with advanced cancer received navelbine (15 mg/m2) as a single iv bolus
injection. At least 1 week later, the patients were given a 2-fold increased dose of navelbine …

The kinetics of distribution and elimination in rats of the antitumor drug navelbine and of two
of its analogues, Na-formyl navelbine and deacetyl navelbine amide, have been studied by …

Navelbine (5'-noranhydrovinblastine), recently developed by Mangeney and co-workers [1,
2], is a potential alternative to natural or semisynthetic vinca alkaloids. It has shown anti …

The pharmacokinetics of vincristine, vindesine, and vinblastine following IV bolus doses of
0.05 mg, 0.10 mg, and 0.20 mg/kg body weight, respectively, were studied in adult male …

We have investigated the pharmacokinetics of the investigational semi-synthetic vinca
alkaloid vinorelbine (navelbine, NVB). The analyses have been performed by using a …

Vinorelbine (Navelbine; Burroughs Wellcome Co, Research Triangle Park, NC; Pierre Fabre
Médicament, Paris, France) is a semisynthetic vinca alkaloid agent that has been structurally …

PURPOSE The feasibility of administering vinorelbine (Navelbine, Burroughs Wellcome Co,
Research Triangle Park, NC), a semisynthetic vinca alkaloid with broad activity, as a liquid …

The pharmacokinetics of vindesine, vincristine, and vinblastine were investigated in patients
with cancer. All drugs were administered rapidly via intravenous injection, and drug levels …

1. KW-2307 (vinorelbine ditartrate, CAS71486-22-1) is a new semisynthetic antitumour vinca
alkaloid. Its pharmacokinetics, distribution and excretion were investigated following …