Four Janus kinases (JAKs)(JAK1, JAK2, JAK3, TYK2) and seven signal transducers and
activators of transcription (STATs)(STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B …

The past decade has witnessed an explosion in trial data on JAK inhibitors (JAKi). These
small molecules target the Janus kinase-signal transducer and activator of transcription (JAK …

Several cytokines involved in inflammatory pathologies signal via the Janus kinase-signal
transducer and activator of transcription pathway. Four JAKs are known: JAK1, JAK2, JAK3 …

Janus kinase (JAK) inhibitors, a novel class of targeted synthetic disease-modifying
antirheumatic drugs (DMARDs), have shown their safety and efficacy in rheumatoid arthritis …

Cytokines are critical mediators of diverse immune and inflammatory diseases. Targeting
cytokines and cytokine receptors with biologics has revolutionized the treatment of many of …

The past three decades have witnessed remarkable advances in our ability to target specific
elements of the immune and inflammatory response, fuelled by advances in both …

Through treatment with biological DMARDs (bDMARDs) or targeted synthetic (tsDMARDs)
such as Janus kinase (JAK) inhibitors in addition to MTX, clinical remission has become a …

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by synovial
inflammation and joint destruction. Considerable advance in the treatment of RA has been …

Janus kinase (JAK) inhibitors have emerged as an effective class of therapies for various
inflammatory diseases such as rheumatoid arthritis (RA). JAK inhibitors function …

Abstract Introduction Janus kinase 2 (JAK2) is involved in the downstream activation of
signal transducer and activator of transcription 3 (STAT3) and STAT5 and is responsible for …