Staphylococcal enterotoxins (SE) and toxic shock syndrome toxin 1 (TSST-1) bind to MHC
class II molecules and the toxin-class II complexes induce proliferation of T cells bearing …

Staphylococcal enterotoxins (SE) activate human T cells in vitro. This requires the presence
of Ia+ accessory cells but does not require processing of the toxin by the accessory cell. We …

Binding of staphylococcal enterotoxin A (SEA) to MHC class II encoded proteins is a
prerequisite for its subsequent activation of a large fraction of T lymphocytes through …

During biosynthesis, class II molecules of the major histocompatibility complex exist as
complexes of the polymorphic alpha and beta chains in association with trimers of the …

Staphylococcal toxic shock syndrome toxin 1 (TSST-1) binds to major histocompatibility
complex class II molecules, and the toxin-class II complexes induce proliferation of T cells …

Staphylococcal enterotoxins (SE) and toxic shock syndrome toxin-1 bind directly to class II
molecules of the MHC and stimulate T cells based predominantly on the V beta segment …

The related staphylococcal toxins staphylococcal enterotoxin A (SEA) and toxic shock
syndrome toxin 1 (TSST-1) are microbial superantigens. They require interaction with class II …

Interaction of staphylococcal exotoxins (SE) with MHC class II molecules plays a central role
in the activation of immune cells by SE. We have recently demonstrated directly that toxic …

Superantigens are thought to make external contacts with major histocompatibility complex
(MHC) class II molecules and with the V beta portion of a T cell antigen receptor (TCR) …

The staphylococcal enterotoxins SEA, SEB, SEC2, and TSST-1 bind to MHC class II
molecules and stimulate polyclonal T cell populations on the basis of the expression of …