[HTML][HTML] Prevalence of single nucleotide polymorphisms in the Plasmodium falciparum multidrug resistance gene (Pfmdr-1) in Korogwe District in Tanzania before and …
TT Thomsen, DS Ishengoma… - The American journal …, 2011 - ncbi.nlm.nih.gov
Tanzania implemented artemether-lumefantrine (AL) as the first-line treatment for
uncomplicated malaria in November of 2006 because of resistance to sulfadoxine …
uncomplicated malaria in November of 2006 because of resistance to sulfadoxine …
[HTML][HTML] Surveillance of artemether-lumefantrine associated Plasmodium falciparum multidrug resistance protein-1 gene polymorphisms in Tanzania
RA Kavishe, P Paulo, RD Kaaya, A Kalinga… - Malaria journal, 2014 - Springer
Background Resistance to anti-malarials is a major public health problem worldwide. After
deployment of artemisinin-based combination therapy (ACT) there have been reports of …
deployment of artemisinin-based combination therapy (ACT) there have been reports of …
[HTML][HTML] Plasmodium falciparum multidrug resistance gene-1 polymorphisms in Northern Nigeria: implications for the continued use of artemether-lumefantrine in the …
Background The analysis of single nucleotide polymorphism (SNPs) in drug-resistance
associated genes is a commonly used strategy for the surveillance of anti-malarial drug …
associated genes is a commonly used strategy for the surveillance of anti-malarial drug …
[HTML][HTML] Selective sweeps and genetic lineages of Plasmodium falciparum multi-drug resistance (pfmdr1) gene in Kenya
Background There are concerns that resistance to artemisinin-based combination therapy
might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with …
might emerge in Kenya and sub-Saharan Africa (SSA) in the same pattern as was with …
[HTML][HTML] Temporal trends of molecular markers associated with artemether-lumefantrine tolerance/resistance in Bagamoyo district, Tanzania
Background Development and spread of Plasmodium falciparum resistance to artemisinin-
based combination therapy (ACT) constitutes a major threat to recent global malaria control …
based combination therapy (ACT) constitutes a major threat to recent global malaria control …
[HTML][HTML] Impact of treatment and re-treatment with artemether-lumefantrine and artesunate-amodiaquine on selection of Plasmodium falciparum multidrug resistance …
V Baraka, HM Mavoko, C Nabasumba, F Francis… - PLoS …, 2018 - journals.plos.org
Background The emergence of resistance against artemisinin combination treatment is a
major concern for malaria control. ACTs are recommended as the rescue treatment …
major concern for malaria control. ACTs are recommended as the rescue treatment …
[HTML][HTML] Prevalence of Plasmodium falciparum anti-malarial resistance-associated polymorphisms in pfcrt, pfmdr1 and pfnhe1 in Muheza, Tanzania, prior to …
Background A report of the chloroquine and amodiaquine resistance pfcrt-SVMNT haplotype
in Tanzania raises concern about high-level resistance to the artesunate-amodiaquine …
in Tanzania raises concern about high-level resistance to the artesunate-amodiaquine …
[HTML][HTML] Molecular surveillance of Plasmodium falciparum resistance to artemisinin-based combination therapies in the Democratic Republic of Congo
DM Mvumbi, TL Bobanga, JMN Kayembe, GL Mvumbi… - PLoS …, 2017 - journals.plos.org
Malaria is a major public health problem in the Democratic Republic of Congo. Despite
progress achieved over the past decade in the fight against malaria, further efforts have to …
progress achieved over the past decade in the fight against malaria, further efforts have to …
[HTML][HTML] Selection of N86F184D1246 haplotype of Pfmrd1 gene by artemether–lumefantrine drug pressure on Plasmodium falciparum populations in Senegal
A Mbaye, B Dieye, YD Ndiaye, AK Bei, A Muna… - Malaria journal, 2016 - Springer
Background The use of artemisinin as a monotherapy resulted in the emergence of
artemisinin resistance in 2005 in Southeast Asia. Monitoring of artemisinin combination …
artemisinin resistance in 2005 in Southeast Asia. Monitoring of artemisinin combination …
Emerging implications of policies on malaria treatment: genetic changes in the Pfmdr-1 gene affecting susceptibility to artemether–lumefantrine and artesunate …
LC Okell, LM Reiter, LS Ebbe, V Baraka, D Bisanzio… - BMJ global …, 2018 - gh.bmj.com
Artemether–lumefantrine (AL) and artesunate–amodiaquine (AS-AQ) are the most
commonly used artemisinin-based combination therapies (ACT) for treatment of …
commonly used artemisinin-based combination therapies (ACT) for treatment of …