The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

Autoantibodies (AA) are a serological hallmark of most autoimmune diseases. In contrast to
genetic markers that show a predisposition for disease development, certain AA serve as …

The critical function of the immune system is to discriminate self from non-self. Tolerance
against self-antigens is a highly regulated process and, in order to maintain it, the immune …

Using three reference disease models‐insulin‐dependent diabetes mellitus (IDDM) as a
prototype of T‐cell mediated organ‐specific autoimmune disease, myasthenia gravis (MG) …

Autoimmune diseases are common diseases in which loss of tolerance within the immune
system results in pathologic immune responses that target either cellular or organ-specific …

The fact that autoimmune diseases share subphenotypes, physiopathological mechanisms
and genetic factors has been called autoimmune tautology, and indicates that they have a …

Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …

Several studies have shown that autoimmune diseases are preceded by a long pre-clinical
phase, and that many autoantibodies can be detected in the serum of asymptomatic subjects …

This volume is THE definitive, completely up-to-date, reference work for ALL researchers
and clinicians working in autoimmunity. Up-to-Date: This is a timely critical review of more …

An overview of the current literature is showing that autoantibodies (AutoAbs) against
cytokines are produced in several pathological conditions, including autoimmune diseases …