Autoimmune diseases are mostly characterized by autoantibodies in the patients' serum or
cerebrospinal fluid, representing diagnostic or prognostic biomarkers. For decades …

Rheumatologists see patients with a range of autoimmune diseases. Phenotyping these
diseases for diagnosis, prognosis and selection of therapies is an ever increasing problem …

Circulating autoantibodies to beta cell antigens are present in the majority of patients with
Type 1 diabetes. These autoantibodies can be detected before and at time of clinical …

Summary Type 1 diabetes (T1D) results from autoimmune destruction of β cells. Insufficient
availability of biomarkers represents a significant gap in understanding the disease cause …

The objective of this study was to determine the prevalence of lupus-related autoimmunity in
a community-based cohort of over 3000 subjects, using a rheumatology registry as a …

Many organ-specific autoimmune diseases are preceded by a long pre-clinical phase, and
several longitudinal cohort studies have shown that patients may carry autoantibodies many …

Objective To evaluate patterns of elevations of isotypes of rheumatoid factor (RF) and anti–
citrullinated protein antibodies (ACPAs) pre–rheumatoid arthritis (RA) diagnosis and post …

Functional autoantibodies are an emerging field of research that focuses on the effects of
these immunoglobulins when they bind to their target molecules. Accumulating information …

Multiple studies demonstrate that there is a period of development of rheumatoid arthritis
(RA) during which there are elevations of disease-related biomarkers, including …

Rheumatoid arthritis (RA) is a prototypical autoimmune arthritis affecting nearly 1% of the
world population and is a significant cause of worldwide disability. Though prior studies …