Cells are the elementary units of living organisms, which are able to carry out many vital
functions. These functions rely on active processes on a microscopic scale. Therefore, they …

The active transport of organelles and other cargos along the axon is required to maintain
neuronal health and function, but we are just beginning to understand the complex …

Long-distance intracellular axonal transport is predominantly microtubule-based, and its
impairment is linked to neurodegeneration. In this study, we present theoretical arguments …

Recent studies on cultured neurons have demonstrated that microtubules are transported
down the axon in the form of short polymers. The transport of these microtubules is …

Microtubules are transported down the axon as short pieces by molecular motor proteins.
One popular idea is that these microtubules are transported by forces generated against the …

BACKGROUND Neurons are polarized cells with extreme geometries. Multiple dendrites
and one axon generally emerge from a single cell body and establish synaptic contacts with …

A striking property of neurons is their extraordinary degree of asymmetry-in the case of
human motor neurons, single cells can extend more than a meter in length. Underlying such …

Great advances in the field of axonal transport have been made in the past year, including
the identification of new molecular motors associated with microtubules and actin. In …

Recent in vitro studies of microtubule-dependent organelle movement have provided a great
deal of information on the molecular mechanism of fast axonal transport. Microtubule …

Neurons require a large amount of intracellular transport. Cytoplasmic polypeptides and
membrane-bounded organelles move from the perikaryon, down the length of the axon, and …