Extensive genomic and transcriptomic heterogeneity in human cancer often negatively
impacts treatment efficacy and survival, thus posing a significant ongoing challenge for …

Single-cell sequencing (SCS) has impacted many areas of cancer research and improved
our understanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and …

The fundamental operative unit of a cancer is the genetically and epigenetically innovative
single cell. Whether proliferating or quiescent, in the primary tumour mass or disseminated …

Precision medicine is emerging as a cornerstone of future cancer care with the objective of
providing targeted therapies based on the molecular phenotype of each individual patient …

Single-cell sequencing (SCS) is a powerful new tool for investigating evolution and diversity
in cancer and understanding the role of rare cells in tumor progression. These methods …

The ability to capture alterations in the genome or transcriptome by next‐generation
sequencing has provided critical insight into molecular changes and programs underlying …

Simple Summary Single-cell sequencing technologies are growing, advancing, and
supporting new opportunities to better understand cancer. A variety of technologies are …

Single-cell sequencing, including genomics, transcriptomics, epigenomics, proteomics and
metabolomics sequencing, is a powerful tool to decipher the cellular and molecular …

Intratumoral heterogeneity is a recently recognized but important feature of cancer that
underlies the various biocharacteristics of cancer tissues. The advent of next-generation …

Advances in genomic technology have enabled the faithful detection and measurement of
mutations and the gene expression profile of cancer cells at the single-cell level. Recently …