The regulation of striated muscle contraction involves changes in the interactions of troponin
and tropomyosin with actin thin filaments. In resting muscle, myosin-binding sites on actin …

Previous work has shown that there are significant differences in the X-ray diffraction
patterns obtained from relaxed and contracting muscles. We show that some of these …

The crystal structure of G-actin monomer has been used together with tropomyosin in a
filament model to explain the low-angle X-ray diffraction data from relaxed and activated …

Muscle thin filaments have been reconstituted from actin and the tropomyosin-troponin
complex and their structure studied in the presence of various Ca 2+ concentrations. The …

The pattern given by contracting frog muscle can be followed with high time resolution using
synchrotron radiation as a high-intensity X-ray source. We have studied the behaviour of the …

X-ray diffraction studies performed over 20 years ago on vertebrate skeletal muscle
suggested that, during activation, tropomyosin movement occurred on thin filaments (Huxley …

The control of vertebrate striated muscle from rest to activity is regulated by the combination
of the regulatory proteins tropomyosin and troponin on the thin actin filament (see reviews by …

X-ray patterns from lobster and crayfish muscles show very clear layer lines from the thin
filaments, well separated from the myosin layer lines. The intensities in patterns from relaxed …

The crystal structure of tropomyosin filaments has been solved to 15 Å resolution by
refinement of models against the diffraction data and heavy atom labeling of cysteine …

In the last decade, improvements in electron microscopy and image processing have
permitted significantly higher resolutions to be achieved (sometimes< 1 nm) when studying …