Applying NGS data to find evolutionary network biomarkers from the early and late stages of hepatocellular carcinoma

YH Wong, CC Wu, CL Lin, TS Chen… - BioMed Research …, 2015 - Wiley Online Library
Hepatocellular carcinoma (HCC) is a major liver tumor (~ 80%), besides hepatoblastomas,
angiosarcomas, and cholangiocarcinomas. In this study, we used a systems biology …

Evolution of network biomarkers from early to late stage bladder cancer samples

YH Wong, CW Li, BS Chen - BioMed Research International, 2014 - Wiley Online Library
We use a systems biology approach to construct protein‐protein interaction networks
(PPINs) for early and late stage bladder cancer. By comparing the networks of these two …

A network biology approach to discover the molecular biomarker associated with hepatocellular carcinoma

L Zhuang, Y Wu, J Han, X Ling, L Wang… - BioMed research …, 2014 - Wiley Online Library
In recent years, high throughput technologies such as microarray platform have provided a
new avenue for hepatocellular carcinoma (HCC) investigation. Traditionally, gene sets …

Core and specific network markers of carcinogenesis from multiple cancer samples

YH Wong, RH Chen, BS Chen - Journal of theoretical biology, 2014 - Elsevier
Cancer is the leading cause of death worldwide and is generally caused by mutations in
multiple proteins or the dysregulation of pathways. Understanding the causes and the …

Transcriptional modules related to hepatocellular carcinoma survival: coexpression network analysis

X Xu, Y Zhou, R Miao, W Chen, K Qu, Q Pang… - Frontiers of medicine, 2016 - Springer
We performed weighted gene coexpression network analysis (WGCNA) to gain insights into
the molecular aspects of hepatocellular carcinoma (HCC). Raw microarray datasets …

Identification of hepatocellular carcinoma related genes with k-th shortest paths in a protein–protein interaction network

M Jiang, Y Chen, Y Zhang, L Chen, N Zhang… - Molecular …, 2013 - pubs.rsc.org
Hepatocellular carcinoma (HCC) is the most common type of liver cancer worldwide and
one of the deadliest cancers in Asia. But at present, effective targets for HCC clinical therapy …

Identification of hepatocellular carcinoma–related genes with a machine learning and network analysis

T Gui, X Dong, R Li, Y Li, Z Wang - Journal of Computational …, 2015 - liebertpub.com
Liver cancer is one of the leading causes of cancer mortality worldwide. Hepatocellular
carcinoma (HCC) is the main type of liver cancer. We applied a machine learning approach …

Bioinformatics analysis to identify the key genes affecting the progression and prognosis of hepatocellular carcinoma

Y Zhang, S Wang, J Xiao, H Zhou - Bioscience reports, 2019 - portlandpress.com
Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, which has poor
outcome. The present study aimed to investigate the key genes implicated in the …

[HTML][HTML] Identification of biomarkers for hepatocellular carcinoma using network-based bioinformatics methods

L Zhang, Y Guo, B Li, J Qu, C Zang, F Li… - European journal of …, 2013 - Springer
Background Hepatocellular carcinoma (HCC) is one of the most common types of cancer
worldwide. Despite several efforts to elucidate molecular mechanisms involved in this …

Identifying hepatocellular carcinoma driver genes by integrative pathway crosstalk and protein interaction network

W Chen, J Jiang, PP Wang, L Gong, J Chen… - DNA and cell …, 2019 - liebertpub.com
In this study, we mined out hepatocellular carcinoma (HCC) driver genes from MEDLINE
literatures by bioinformatics methods of pathway crosstalk and protein interaction network …