The conjugation of ubiquitin and related modifiers to selected proteins represents a general
mechanism to alter the function of these protein targets, thereby increasing the complexity of …

Ubiquitin modification of many protein targets within cells plays important roles in a variety of
biological processes. Among these are regulation of gene expression, regulation of cell …

Ubiquitination is a post-translational modification of proteins involved in a variety of cellular
processes. Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin …

Ubiquitination involves the attachment of ubiquitin to lysine residues on substrate proteins or
itself, which can result in protein monoubiquitination or polyubiquitination. Ubiquitin …

Protein ubiquitylation is a recognized signal for protein degradation. However, it is
increasingly realized that ubiquitin conjugation to proteins can be used for many other …

Covalent modification of eukaryotic proteins by ubiquitin and ubiquitin-like proteins is
involved in the control of many–if not all–cellular processes including protein quality control …

I. Introduction..................................................................... 139 II. Alzheimer's
Disease............................................................... 140 A. The Ubiquitin System as a Neurotissue …

Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies …

Ubiquitin regulates a wide variety of biological functions by modifying diverse substrates, via
many different conjugation types. Classically, the C-terminus of ubiquitin conjugates to …

The capacity for exquisite regulation of ubiquitylation provides eukaryotic cells with a means
to fine-tune both protein function and levels. This complex set of processes affects myriad …