Ubiquitin in health and disease Page 1 Biochimica et Biophysico Acta, 1089 (1991) 141-157 ©
1991 Elsevier Science Publishers BV 0167-4781/91/$03.50 ADONIS 016747819100139W …

An important problem concerning regulation of the ubiquitin-proteasome system (UPS)
relates to the stability of its own components and the mechanisms of their degradation. It has …

Ubiquitin is a common demoninator in the targeting of substrates to all three major protein
degradation pathways in mammalian cells: the proteasome, the lysosome, and the …

Ubiquitination is a post-translational modification that generally directs proteins for
degradation by the proteasome or by lysosomes. However, ubiquitination has been …

Ubiquitylation (also known as ubiquitination) regulates essentially all of the intracellular
processes in eukaryotes through highly specific modification of numerous cellular proteins …

Protein modification by ubiquitin and ubiquitin-like molecules is a critical regulatory process.
Like most regulated protein modifications, ubiquitination is reversible. Deubiquitination, the …

Ubiquitin‐mediated proteolysis is a major pathway of protein degradation that regulates
numerous cellular processes. An understanding of the circumstances that contribute to the …

Ubiquitin is a small protein that can be covalently linked to itself or other proteins, either as
single ubiquitin molecules or as chains of polyubiquitin. Addition of ubiquitin to a target …

The ubiquitin–proteasome system of intracellular proteolysis is essential for cell viability. We
propose the concept that neurodegenerative diseases such as Alzheimer's and Parkinson's …

The ubiquitin proteasome pathway controls the cellular degradation of~ 80–90% of the
proteome in a highly regulated manner. In this pathway, E3 ligases are responsible for the …