Exercise intolerance is a cardinal symptom of pulmonary arterial hypertension (PAH) and
strongly impacts patients9 quality of life (QoL). Although central cardiopulmonary …

Pulmonary arterial hypertension (PAH) is a chronic disease with poor prognosis and
important exercise limitation despite the proliferation of treatment options in the last decade …

Introduction: Exercise intolerance in pulmonary hypertension (PH) is a major factor affecting
activities of daily living and quality of life. Evaluation strategies (ie, non-invasive and …

Pulmonary arterial hypertension (PAH) is associated with symptoms of dyspnea and fatigue,
which contribute to exercise limitation. The origins and significance of dyspnea and fatigue …

Pulmonary arterial hypertension (PAH) is characterized by a continuous increase in pre-
capillary pulmonary vascular resistance (PVR) with a progressive reduction of cardiac output …

The lungs are the only organ that receives the entire cardiac output with every stroke. The
pulmonary circulation is normally a high-flow, low-resistance, low-pressure system that …

Pulmonary hypertension (PH) is a chronic, debilitating condition which gravely affects
exercise tolerance and quality of life. Though most therapies focus purely on medical …

Background The symptom for identification of pulmonary arterial hypertension (PAH) is
dyspnea on exertion, with a concomitant decrease in exercise capacity. Even patients with …

Respiratory and limb muscle dysfunction is emerging as an important pathophysiological
abnormality in pulmonary arterial hypertension (PAH). Muscle abnormalities appear to occur …

Background A majority of patients with idiopathic pulmonary arterial hypertension (IPAH)
display persistent exercise intolerance despite new specific therapies. Whether patients with …