While the role of autophagy in the physiology of endocrine organs and the development of
metabolic disorders or diabetes has been investigated, the relationship between the …

Diabetes mellitus is characterized by decreased insulin secretion and action. Decreased
insulin secretion results from a reduction in pancreatic β-cell mass and function. Apoptosis …

Insulin is a paramount anabolic hormone that promotes energy-storage in adipose tissue,
skeletal muscle and liver, and these responses are significantly attenuated in insulin …

The prevalence of obesity is increasing rapidly and is closely associated with a variety of
metabolic diseases. Recent studies have suggested that autophagy is likely to play an …

An emerging body of evidence supports a role for autophagy in the pathophysiology of type
1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances …

Autophagy, a ubiquitous catabolic pathway involved in both cell survival and cell death, has
been implicated in many age‐associated diseases. Recent findings have shown autophagy …

Diabetic nephropathy is a serious complication of diabetes mellitus, and its prevalence has
been increasing worldwide. Therefore, there is an urgent need to identify a new therapeutic …

The incidence of diabetes has been increasing in recent decades which is affecting the
population of both, developed and developing countries. Diabetes is associated with micro …

Pancreatic β-cells play a key role in glucose homeostasis in mammals. Although large-scale
protein synthesis and degradation occur in pancreatic β-cells, the mechanism underlying …

The process of macroautophagy (referred to hereafter as autophagy), is generally
characterized by the prominent formation of autophagic vesicles in the cytoplasm. In the past …