Pancreatic beta-cell dysfunction is central to the development and worsening of type 2
diabetes. Whereas beta-cell apoptosis plays a major role in reducing beta-cell mass in …

Autophagy is the major mechanism involved in degradation and recycling of intracellular
components, and its alterations have been proposed to cause beta cell dysfunction. In this …

Autophagy is a cellular pathway crucial for development, differentiation, survival and
homeostasis. Autophagy can provide protection against aging and a number of pathologies …

Type 2 diabetes mellitus is characterized by insulin resistance and failure of pancreatic β‐
cells producing insulin. Mitochondrial dysfunction may play a role in both processes of …

Autophagy plays an important role in the regulation of cellular homeostasis through
elimination of aggregated proteins, damaged organelles, and intracellular pathogens …

Diabetic Encephalopathy (DE) is one of the complications of diabetes mellitus (DM) in the
central nervous system. Up to now, the mechanisms of DE are not fully discussed by the …

Dysregulation of autophagy contributes to aging and to diseases such as
neurodegeneration, cardiomyopathy, and cancer. The paper by Yang et al.(2010) in this …

Autophagy is a self-degradative pathway involving intracellular substance degradation and
recycling. Recently, this process has attracted a great deal of attention for its fundamental …

Numerous studies have established a link between autophagy and aging; however, the
relationship has not been clearly defined. Aging is a very complex process caused by the …

Autophagy is a dynamic process that degrades and recycles cellular organelles and
proteins to maintain cell homeostasis. Alterations in autophagy occur in various diseases; …