Numerous studies have established a link between autophagy and aging; however, the
relationship has not been clearly defined. Aging is a very complex process caused by the …

Autophagy plays a crucial role in the maintenance of cellular nutrient balance and the
function of organelles such as mitochondria or the endoplasmic reticulum, which are …

Diabetic kidney disease (DKD) is a frequent, potentially devastating complication of diabetes
mellitus. Several factors are involved in its pathophysiology. At a cellular level, diabetic …

The global prevalence of metabolic disorders is an immediate threat to human health.
Genetic features, environmental aspects and lifestyle changes are the major risk factors …

Autophagy is a dynamic process which plays an important role in cellular homeostasis
through recycling of damaged proteins and organelles. Chronic hyperglycemia associated …

Dysregulation of autophagy is an important underlying cause in the onset and progression
of many metabolic diseases, including diabetes. Studies in animal models and humans …

Autophagy is inhibited by the insulin-amino acid-mTOR signaling pathway. Two papers in
this issue of Cell Metabolism (Ebato et al., 2008; Jung et al., 2008) provide evidence that …

Autophagy is an evolutionarily conserved process that contributes to maintain cell
homeostasis. Although it is strongly regulated by many extracellular factors, induction of …

Autophagy is a kind of cell biological process that maintains the cell's energy level under
nutrient-poor conditions, regulates the turnover of abnormal or aged proteins, and disposes …

Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …