Background Pathophysiology of obesity is closely associated with enhanced autophagy in
adipose tissue (AT). Autophagic process can promote survival or activate cell death …

Abstract Purpose of Review Autophagy promotes cellular health in response to various
cellular stresses and to changes in nutrient conditions. In this review, we focus on the role of …

Autophagy is an evolutionarily conserved machinery for bulk degradation of cytoplasmic
components. Here, we report upregulation of autophagosome formation in pancreatic beta …

Simple Summary With the mortality rate of pancreatic cancer predicted to rise over the
coming years, it is essential that effective treatment strategies are developed as soon as …

The inflammatory response is an energy-intensive process. Consequently, metabolism is
closely associated with immune function. The autophagy machinery plays a role in …

Objectives: Autophagy is a highly regulated process that has an important role in the control
of a wide range of cellular functions, such as organelle recycling, nutrient availability and …

Aims/hypothesis Beta cell loss contributes to type 2 diabetes, with increased apoptosis
representing an underlying mechanism. Autophagy, ie the physiological degradation of …

Diabetes mellitus is a chronic metabolic disorder that has a complex molecular and cellular
pathophysiology, resulting in its dynamic progression and that may show differing responses …

Diabetic nephropathy (DN) is the most common cause of end-stage kidney disease
worldwide, and is associated with increased morbidity and mortality in patients with both …

Protein degradation in eukaryotic cells is mediated primarily by the ubiquitin-proteasome
system and autophagy. Turnover of protein aggregates and other cytoplasmic components …