An acute myocardial infarction, particularly one that is large and transmural, can produce
alterations in the topography of both the infarcted and noninfarcted regions of the ventricle …

Improvement in the methodological approach to the analysis of the myocardium has
provided clear evidence of cardiac myocyte proliferation, questioning the general belief that …

BACKGROUND The mechanisms of ventricular enlargement and dysfunction during
postinfarct remodeling remain largely unknown. Although global left ventricular architectural …

Abstract The Frank-Starling mechanism, by which load directly regulates muscle length and
thus performance is the means by which the mechanics and energetics of cardiac muscle …

Ischemic cardiomyopathy is an anatomic condition emanating from a sustained imbalance
between oxygen supply and demand of the heart that, in turn, leads to myocyte loss with …

Severe myocardial ischemia, when sustained, leads to a predictable sequence of events,
including myocardial necrosis, expansion of the infarct, and later its replacement by scar …

To determine whether heart failure is a consequence of alterations in cardiac cellular
performance, myocytes were isolated from Fischer 344 rats at 4, 12, 20, and 29 mo of age …

To determine the effects of chronic anemia on the functional and structural characteristics of
the heart, 1-month-old male rats were fed a diet deficient in iron and copper, which led to a …

BACKGROUND Chronic ischemic heart disease may lead to ventricular dilation and
congestive heart failure (ischemic cardiomyopathy [ICM]). The changes in cardiac myocyte …

Heart failure continues to be a major source of death and disability, and concepts and
understanding of the disorder continue to evolve. There is now widespread recognition that …