Objective The diversity of the tumour microenvironment (TME) of intrahepatic
cholangiocarcinoma (iCCA) has not been comprehensively assessed. We aimed to …

Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a severe malignant tumor in
which the standard therapies are mostly ineffective. The biological significance of the …

Background & Aims Cholangiocarcinoma (CCA), a deadly malignancy of the bile ducts, can
be classified based on its anatomical location into either intrahepatic (iCCA) or extrahepatic …

Background Although molecular characterization of iCCA has been studied recently,
integrative analysis of molecular and clinical characterization has not been fully established …

Background Immune microenvironment is well recognized as a critical regulator across
cancer types, despite its complex roles in different disease conditions. Intrahepatic …

BACKGROUND & AIMS: Cholangiocarcinoma, the second most common liver cancer, can
be classified as intrahepatic cholangiocarcinoma (ICC) or extrahepatic cholangiocarcinoma …

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive primary liver malignancy with an
increasing incidence worldwide. Recently, histopathologic classification of small duct type …

Background and Aims Cholangiocarcinoma (CCA) is a deadly and highly therapy‐refractory
cancer of the bile ducts, with early results from immune checkpoint blockade trials showing …

Intrahepatic cholangiocarcinoma (iCCA) exhibits extensive intratumoral heterogeneity and
an extremely high mortality rate. Here, we performed whole-exome sequencing, RNA …

PURPOSE Biliary tract cancers (BTCs) are aggressive cancers that carry a poor prognosis.
An enhanced understanding of the immune landscape of anatomically and molecularly …