Curcumin for malaria therapy

RC Reddy, PG Vatsala, VG Keshamouni… - Biochemical and …, 2005 - Elsevier
Malaria remains a major global health concern. New, inexpensive, and effective antimalarial
agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule …

Synthesis and exploration of novel curcumin analogues as anti-malarial agents

S Mishra, K Karmodiya, N Surolia, A Surolia - Bioorganic & medicinal …, 2008 - Elsevier
Curcumin, a major yellow pigment and active component of turmeric, has been shown to
possess anti-inflammatory and anti-cancer activities. Recent studies have indicated that …

[HTML][HTML] Cellular Effects of Curcumin on Plasmodium falciparum Include Disruption of Microtubules

R Chakrabarti, PS Rawat, BM Cooke, RL Coppel… - PLoS …, 2013 - journals.plos.org
Curcumin has been widely investigated for its myriad cellular effects resulting in reduced
proliferation of various eukaryotic cells including cancer cells and the human malaria …

Cytotoxic Effect of Curcumin on Malaria Parasite Plasmodium falciparum: Inhibition of Histone Acetylation and Generation of Reactive Oxygen Species

L Cui, J Miao, L Cui - Antimicrobial agents and chemotherapy, 2007 - Am Soc Microbiol
The emergence of multidrug-resistant parasites is a major concern for malaria control, and
development of novel drugs is a high priority. Curcumin, a natural polyphenolic compound …

Curcumin-artemisinin combination therapy for malaria

DN Nandakumar, VA Nagaraj… - Antimicrobial agents …, 2006 - Am Soc Microbiol
Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in
culture. In vivo, 3 oral doses of curcumin following a single injection of α, β-arteether to …

[HTML][HTML] Nanocurcumin is superior to native curcumin in preventing degenerative changes in Experimental Cerebral Malaria

C Dende, J Meena, P Nagarajan, VA Nagaraj… - Scientific reports, 2017 - nature.com
Curcumin has many pharmacological activities despite its poor bioavailability and in vivo
stability. Here, we show that a nanoformulated curcumin (PLGA-curcumin) has better …

[HTML][HTML] The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria

PN Mimche, D Taramelli, L Vivas - Malaria journal, 2011 - Springer
The clinical manifestations of cerebral malaria (CM) are well correlated with underlying
major pathophysiological events occurring during an acute malaria infection, the most …

Curcumin and its analogues: a potential natural compound against HIV infection and AIDS

S Prasad, AK Tyagi - Food & function, 2015 - pubs.rsc.org
No safe and effective cure currently exists for human immunodeficiency virus (HIV).
However, antiretroviral therapy can prolong the lives of HIV patients and lowers the …

Curcumin and curcumin-loaded nanoparticles: Antipathogenic and antiparasitic activities

M Rai, AP Ingle, R Pandit, P Paralikar… - Expert review of anti …, 2020 - Taylor & Francis
Introduction: Curcumin is an important bioactive compound present in Curcuma longa, and
is well known for its bioactivities such as anti–inflammatory, anticancer, antimicrobial …

Latent activity of curcumin against leishmaniasis in vitro

D Saleheen, SA Ali, K Ashfaq, AA Siddiqui… - Biological and …, 2002 - jstage.jst.go.jp
MATERIALS AND METHODS Parasite Cultures All the promastigote cultures of both the
reference and local Pakistani leishmanial strains were maintained in blood agar based bi …