Validation of phospholipase A2 receptor direct immunofluorescence staining in the diagnosis of primary membranous glomerulonephritis

P Dai, D Campbell, S Culican, DA Brown, K Byth… - Pathology, 2020 - Elsevier
Distinguishing between primary and secondary subtypes of membranous
glomerulonephritis (MGN) is critical for its clinical management. We prospectively compared …

PLA2R immunohistochemistry staining in membranous glomerulopathy: a challenging stain to interpret but a potentially useful diagnostic tool

R Del Sordo, C Covarelli, R Brugnano… - Applied …, 2021 - journals.lww.com
Circulating autoantibodies to phospholipase A2 receptor (PLA2R-Ab) are detected in> 70%
of patients with primary membranous glomerulonephritis (MGN). Detection of PLA2R …

An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis

E Hoxha, S Harendza, G Zahner… - Nephrology Dialysis …, 2011 - academic.oup.com
Background. The recent finding that phospholipase-A2-receptor antibodies (PLA2R-AB)
may play a role in the development of primary membranous glomerulonephritis (MGN) offers …

Validation of a phospholipase A2 receptor antibody ELISA in an Australian cohort with membranous glomerulonephritis

L Ong, R Silvestrini, J Chapman, DA Fulcher, MW Lin - Pathology, 2016 - Elsevier
Summary A commercial PLA2R Ab ELISA was validated by examining its ability to
distinguish primary from secondary membranous nephropathy, correlating results with …

The usefulness of phospholipase A2 receptor and IgG4 detection in differentiation primary membranous nephropathy from secondary membranous nephropathy in …

M Yeo, YH Kim, DE Choi, SY Choi… - Applied …, 2018 - journals.lww.com
Membranous nephropathy (MGN) is the most common cause of the nephrotic syndrome in
adults. Most cases of MGN are primary, but secondary MGN are frequently encountered …

Ultrasensitive quantitation of anti-phospholipase A2 receptor antibody as a diagnostic and prognostic indicator of idiopathic membranous nephropathy

Q Zhang, B Huang, X Liu, B Liu, Y Zhang, Z Zhang… - Scientific Reports, 2017 - nature.com
Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful for affirming the diagnosis of
idiopathic membranous nephropathy (IMN). Time-resolved fluoroimmunoassay (TRFIA) is …

Immunohistochemical glomerular expression of phospholipase A2 receptor in primary and secondary membranous nephropathy: A retrospective study in an Indian …

S Roy, A Korula, G Basu, S Jacob, S Varughese… - Nephron Extra, 2017 - karger.com
Background: Limited published literature exists on the utility and standardization of anti-
phospholipase A2 receptor (anti-PLA2R) immunohistochemistry (IHC) for the diagnosis of …

Anti-phospholipase A2 receptor antibody as prognostic indicator in idiopathic membranous nephropathy

YG Kim, YW Choi, SY Kim, JY Moon, CG Ihm… - American journal of …, 2015 - karger.com
Background: Anti-phospholipase A2 receptor antibody (PLA2R-Ab) is useful in diagnosing
idiopathic membranous nephropathy (IMN). We investigated the clinical relevance of PLA2R …

[HTML][HTML] Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies

CP Larsen, NC Messias, FG Silva, E Messias… - Modern Pathology, 2013 - Elsevier
Autoantibody formation directed against phospholipase A2 receptor (PLA2R) 1 is the
underlying etiology in most cases of primary membranous glomerulopathy. This new …

Combined evaluation of glomerular phospholipase A2 receptor and immunoglobulin G subclass in membranous nephropathy

K Ueki, A Tsuchimoto, Y Matsukuma… - Clinical Kidney …, 2024 - academic.oup.com
Background Phospholipase A2 receptor (PLA2R) is a major target antigen in idiopathic
membranous nephropathy (MN). Anti-PLA2R antibodies are mainly of the immunoglobulin G …