The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

Increasing evidence demonstrates that oxidative stress causes damage to cell function with
aging and is involved in a number of age-related disorders including atherosclerosis, ar …

It has now been established through multiple lines of evidence that oxidative stress is an
early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus …

Oxidative stress is a marker of neurodegeneration and has been recently shown to be also
involved in the early stages of the pathogenesis of various neurodegenerative disorders. In …

Alzheimer's disease is a neurodegenerative disorder comprising multisystem atrophies
probably caused by multifactorial processes. The disease is characterized by typical …

Alzheimer's disease has a multifactorial pathogenesis. Among the various factors involved,
this review examines, in particular, the possibility of oxidative stress, meaning an imbalance …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease
associated with dementia in the elderly. Although the initiating events are still unknown, it is …

As the number of patients with Alzheimer's disease (AD) increases, it brings great suffering
to their families and causes a heavy socioeconomic burden to society. A vast amount of …

In this review, we consider comparative aspects of the biology and pathology of oxygen
radicals in neurodegenerative disease and how these findings have influenced our concept …

There is increasing evidence that free radical damage to brain lipids, carbohydrates,
proteins, and DNA is involved in neuron death in neurodegenerative disorders. The largest …