A new reality: achieving cholesterol-lowering goals in clinical practice

A Gaw - Atherosclerosis Supplements, 2002 - Elsevier
Physicians often fail to achieve recommended low-density lipoprotein (LDL) cholesterol
goals for their patients using lipid-lowering therapies in the primary care setting. A variety of …

Drug safety evaluation of rosuvastatin

PP Toth, TD Dayspring - Expert opinion on drug safety, 2011 - Taylor & Francis
Introduction: Rosuvastatin is a highly efficacious statin approved for use throughout the
world. Rosuvastatin has been exhaustively evaluated in the setting of a broad variety of …

[引用][C] Achieving lipid goals in real life: the DISCOVERY-UK study

A Middleton, A Fuat - British Journal of Cardiology, 2006 - MILESTONE MEDICAL MEDIA

Pharmacokinetics of rosuvastatin: a systematic review of randomised controlled trials in healthy adults

R Kanukula, A Salam, A Rodgers, B Kamel - Clinical Pharmacokinetics, 2021 - Springer
Background Rosuvastatin is a lipid-lowering drug that works by inhibiting 3-hydroxy-3-
methylglutaryl coenzyme A reductase, the rate-limiting enzyme responsible for producing …

Long-term efficacy and safety of rosuvastatin 40 mg in patients with severe hypercholesterolemia

EA Stein, J Amerena, CM Ballantyne, E Brice… - The American journal of …, 2007 - Elsevier
Patients with elevated low-density lipoprotein (LDL) cholesteral levels are at high risk of
cardiovascular events but are often undertreated and fail to achieve lipid goals. This open …

Effect of rosuvastatin compared with other statins on lipid levels and National Cholesterol Education Program goal attainment for low‐density lipoprotein cholesterol in …

MF Bullano, DA Wertz, GW Yang… - … : The Journal of …, 2006 - Wiley Online Library
Study Objective. To compare, in a usual care setting, the effects of rosuvastatin and other 3‐
hydroxy‐3‐methylglutaryl coenzyme A inhibitors (statins) on lipid levels and on goal …

Rosuvastatin: efficacy, safety and clinical effectiveness

H Soran, P Durrington - Expert opinion on pharmacotherapy, 2008 - Taylor & Francis
Background: Rosuvastatin is a fully synthetic statin developed by AstraZeneca. It is a
competitive inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA reductase. Objective: We reviewed …

Comparison of the efficacy of rosuvastatin versus atorvastatin, simvastatin, and pravastatin in achieving lipid goals: results from the STELLAR trial

JM McKenney, PH Jones, MA Adamczyk… - … medical research and …, 2003 - Taylor & Francis
SUMMARY In the Statin Therapies for Elevated Lipid Levels compared Across doses to
Rosuvastatin (STELLAR) trial, the efficacy of rosuvastatin calcium (Crestor) was compared …

An evaluation of rosuvastatin: pharmacokinetics, clinical efficacy and tolerability

JR Crouse III - Expert Opinion on Drug Metabolism & Toxicology, 2008 - Taylor & Francis
Background: The HMG Co-A reductase inhibitors (statins) are the most efficacious agents for
lowering cholesterol. Statins reduce clinical cardiovascular events and are generally well …

The comparative safety of rosuvastatin: a retrospective matched cohort study in over 48 000 initiators of statin therapy

AT McAfee, EE Ming, JD Seeger… - … and drug safety, 2006 - Wiley Online Library
Purpose The purpose of this study was to compare incidence rates of hospitalization
associated with rhabdomyolysis, myopathy, renal, or hepatic dysfunction, and of in‐hospital …