Recent US guidelines expand the indications for high-intensity statin therapy, yet data on the
safety of attaining very low-density lipoprotein cholesterol (LDL-C) levels are scarce. Among …

The safety and tolerability of rosuvastatin were assessed (as of August 2003) using data
from 12,400 patients who received 5 to 40 mg of rosuvastatin in a multinational phase II/III …

Rosuvastatin is a synthetic enantiomer that is hepatoselective, relatively hydrophilic and has
minimal metabolism via the cytochrome P450 3A4 system (similar to pravastatin) …

Objective The primary objective of this trial was to compare the efficacy of rosuvastatin with
that of pravastatin and simvastatin for lowering low-density lipoprotein cholesterol (LDL-C) …

Results from clinical trials and clinical practice have shown statins to be generally well
tolerated with a low frequency of clinically relevant side effects. Nevertheless, there are rare …

Background Although the effectiveness of statins is well established, analyses of
spontaneous adverse event reports have recently questioned the safety of rosuvastatin …

BACKGROUND:: Rosuvastatin is a new statin indicated to reduce elevated levels of total
cholesterol, low-density lipoprotein cholesterol (LDL-C), and triglycerides and to increase …

Background and objective Despite the favorable effects of reduction of low-density
lipoprotein-cholesterol (LDL-C) levels in decreasing the risk of coronary heart disease, many …

Background Reducing low-density lipoprotein cholesterol (LDL-C) levels decreases
cardiovascular risk in direct proportion to the decrease in LDL-C. Design The aim of this …

Objective: To evaluate and compare the efficacy and safety of rosuvastatin versus
atorvastatin in a high-risk Chinese population with hypercholesterolemia. Research design …