The formalin model is widely used for evaluating the effects of analgesic compounds in
laboratory animals. Injection of formalin into the hind paw induces a biphasic pain response; …

Background TRPA1 has been implicated in both chemo-and mechanosensation. Recent
work demonstrates that inhibiting TRPA1 function reduces mechanical hypersensitivity …

The formalin test still surprises with its biphasic pain-related behavior resulting from a
quiescent interphase that does not occur with other algogenic compounds and remains …

Mechanical hyperalgesia is a clinically-relevant form of pain sensitization that develops
through largely unknown mechanisms. TRPA1, a Transient Receptor Potential ion channel …

Formalin-evoked trigeminal pain behavior depends on TRPV4 calcium-permeable
channels, also on MEK-ERK signaling in trigeminal ganglion neurons. ABSTRACT …

Transient receptor potential A1 (TRPA1) ion channel senses a variety of noxious stimuli and
is involved in nociception. Many TRPA1 agonists covalently modify the channel, which can …

TRPA1 is an excitatory ion channel targeted by pungent irritants from mustard and garlic.
TRPA1 has been proposed to function in diverse sensory processes, including thermal …

Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is expressed in
muscle afferents and direct activation of these receptors induces acute mechanical …

Introduction Chronic pain affects approximatively 30–50% of the population globally.
Pathologies such as migraine, diabetic neuropathy, nerve injury and treatment with …

Proinflammatory agents trypsin and mast cell tryptase cleave and activate PAR2, which is
expressed on sensory nerves to cause neurogenic inflammation. Transient receptor …