TSPO ligands PK11195 and midazolam reduce NLRP3 inflammasome activation and proinflammatory cytokine release in BV-2 cells
H Feng, Y Liu, R Zhang, Y Liang, L Sun… - Frontiers in Cellular …, 2020 - frontiersin.org
Neuroinflammation related to microglial activation plays an important role in
neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive …
neurodegenerative diseases. Translocator protein 18 kDa (TSPO), a biomarker of reactive …
TSPO Ligands Protect against Neuronal Damage Mediated by LPS‐Induced BV‐2 Microglia Activation
B Ma, Y Liu, X Zhang, R Zhang, Z Zhang… - Oxidative Medicine …, 2022 - Wiley Online Library
Neuroinflammation is a critical pathological process of neurodegenerative diseases, and
alleviating the inflammatory response caused by abnormally activated microglia might be …
alleviating the inflammatory response caused by abnormally activated microglia might be …
TSPO knockdown attenuates OGD/R-induced neuroinflammation and neural apoptosis by decreasing NLRP3 inflammasome activity through PPARγ pathway
K Wang, G Wang, B Zhou - Brain Research Bulletin, 2022 - Elsevier
Ischemic stroke is a cerebrovascular disease which is related to brain function loss induced
by cerebral ischemia. Translocator protein (TSPO) is an important regulator in inflammatory …
by cerebral ischemia. Translocator protein (TSPO) is an important regulator in inflammatory …
The TSPO ligands 2-Cl-MGV-1, MGV-1, and PK11195 differentially suppress the inflammatory response of BV-2 microglial cell to LPS
M Azrad, N Zeineh, A Weizman, L Veenman… - International Journal of …, 2019 - mdpi.com
The 18 kDa Translocator Protein (TSPO) is a marker for microglial activation as its
expression is enhanced in activated microglia during neuroinflammation. TSPO ligands can …
expression is enhanced in activated microglia during neuroinflammation. TSPO ligands can …
[HTML][HTML] Systematic analysis of translocator protein 18 kDa (TSPO) ligands on toll-like receptors-mediated pro-inflammatory responses in microglia and astrocytes
JW Lee, H Nam, SW Yu - Experimental neurobiology, 2016 - ncbi.nlm.nih.gov
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive
microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain …
microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain …
Pristimerin inhibits MMP-9 expression and cell migration through attenuating NOX/ROS-dependent NF-κB activation in rat brain astrocytes challenged with LPS
Purpose Neuroinflammation plays a crucial role in neurodegenerative diseases. Matrix
metalloproteinases (MMPs) are a landmark of neuroinflammation. Lipopolysaccharide (LPS) …
metalloproteinases (MMPs) are a landmark of neuroinflammation. Lipopolysaccharide (LPS) …
Ginkgolide B inhibits NLRP3 inflammasome activation and promotes microglial M2 polarization in Aβ1-42-induced microglia cells
Y Zhang, Y Zhao, J Zhang, Y Gao, S Li, C Chang… - Neuroscience …, 2021 - Elsevier
Nucleotide-binding oligomerization domain (NOD)-like receptor protein 3 (NLRP3)
inflammasome-mediated chronic neuroinflammation plays a crucial role in the progression …
inflammasome-mediated chronic neuroinflammation plays a crucial role in the progression …
[HTML][HTML] Caspase-1 inhibition attenuates activation of BV2 microglia induced by LPS-treated RAW264. 7 macrophages
Y Pan, B Shen, Q Gao, J Zhu, J Dong… - Journal of Biomedical …, 2016 - ncbi.nlm.nih.gov
Neuroinflammation has been recognized as a factor in the pathogenesis of
neurodegenerative diseases. Emerging evidence suggests that peripheral inflammation …
neurodegenerative diseases. Emerging evidence suggests that peripheral inflammation …
TSPO-specific ligand vinpocetine exerts a neuroprotective effect by suppressing microglial inflammation
YY Zhao, JZ Yu, QY Li, CG Ma, CZ Lu, BG Xiao - Neuron glia biology, 2011 - cambridge.org
Vinpocetine has long been used for cerebrovascular disorders and cognitive impairment.
Based on the evidence that the translocator protein (TSPO, 18 kDa) was expressed in …
Based on the evidence that the translocator protein (TSPO, 18 kDa) was expressed in …
Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia
Z Fan, Z Liang, H Yang, Y Pan, Y Zheng… - Journal of …, 2017 - Springer
Background Emerging evidence indicates that nod-like receptor family, pyrin domain-
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …
containing 3 (NLRP3) inflammasome-induced inflammation plays a crucial role in the …