Hypoxia-inducible factor (HIF) is a sequence-specific DNA-binding protein that can promote
or repress the transcription of a broad range of genes that are involved in maintaining …

Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor that is critical for
hypoxic induction of a number of physiologically important genes. We present evidence that …

Oxygen homeostasis is a cornerstone of both the physiology and intermediary metabolism
systems. Despite the explosion of knowledge brought about by recombinant DNA …

Hypoxia‐inducible factor (HIF) is a transcription complex which responds to changes in
oxygen, providing cells with a master regulator that coordinates changes in gene …

The basic helix-loop-helix-Per-ARNT-Sim–proteins hypoxia-inducible factor (HIF)-1α and
HIF-2α are the principal regulators of the hypoxic transcriptional response. Although highly …

Hypoxia-inducible factors are heterodimeric DNA-binding complexes that control the
hypoxia responses of several genes and regulate the adaptive responses to the lack of …

Hypoxia inducible factors (HIFs) are heterodimeric transcription factors that regulate a
number of adaptive responses to low oxygen tension. They are composed of α-and β …

The transcription factor hypoxia inducible factor α‐subunit (HIFα) is pivotal in the cellular
response to the stress of hypoxia. Post‐translational modification of HIFα by hydroxylase …

Hypoxia-inducible factor 1 (HIF-l) accumulates in the nuclei of mammalian cells exposed to
reduced O2 tension in a time-and O2 concentration-dependent manner. HIF-1 plays an …

The hypoxia-inducible transcription factor (HIF) controls (in an oxygen-dependent manner)
the expression of a large number of genes whose products are involved in the response of …