We have characterized the in vitro pharmacological profile of the new potent and selective
A2a adenosine receptor antagonist SCH 58261 [7-(2-phenylethyl)-5-amino-2-(2-furyl) …

A series of pyrazolo [4, 3-e]-1, 2, 4-triazolo [1, 5-c] pyrimidine derivatives (10a− o, q, r),
bearing alkyl and aralkyl chains on positions 7 and 8, were synthesized in the attempt to …

1 This paper describes the in vitro pharmacology of ZM 241385 (4‐(2‐[7‐amino‐2‐(2‐
furyl)[1, 2, 4]‐triazolo [2, 3‐a][1, 3, 5] triazin‐5‐yl amino] ethyl) phenol), a novel non‐xanthine …

Abstract 8-(3, 4-Dimethoxystyryl)-1, 3-dipropyl-7-methylxanthine exhibited high affinity and
selectivity for adenosine A 2A receptors in binding assay using rat striatal A 2A receptors …

In the early 1990s it became clear that the A2A adenosine receptor had characteristics that
made it distinct from the other A1, A2B and A3 adenosine receptors. Great progress has …

Previous studies in our laboratory identified N6-endonorbornyl-9-methyladenine (N-0861)
as a highly selective (100-fold) A1-adenosine receptor antagonist (KB= 500 nM). However …

The xanthines currently represent the most potent class of adenosine receptor antagonists.
However, known derivatives of xanthine show little difference in antagonist potency between …

Adenosine regulates a wide range of physiological functions f! l, _ through specific cell
membrane receptors. On the basis of pharmacological I" til, studies and molecular cloning …

Due to the clearly demonstrated receptor-receptor interaction between adenosine A (2A)
and dopamine D (2) receptors in the basal ganglia, the discovery and development of potent …

Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines,
pyrrolo[2,3-d]pyrimidines and 6-arylpurines - ScienceDirect Skip to main contentSkip to …