Sickle cell anemia (SCA) is a genetic disease caused by the homozygosity of the HBB: c.
20A> T mutation, which results in the production of hemoglobin S (HbS). In hypoxic …

Sickle cell anemia (SCA) is an autosomal recessive disorder, with Mendelian inheritance
pattern, caused by a missense mutation in the β-polypeptide chain of the hemoglobin B …

Overt stroke in adults with sickle cell anemia (SCA) continues to be a major cause of
morbidity and mortality, while no evidence-based strategy for prevention has been reached …

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV)
subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African …

Sickle cell disease (SCD) is an inherited hemoglobinopathy in which affected hemoglobin
polymerizes under hypoxic conditions resulting in red cell distortion and chronic hemolytic …

Sickle cell anemia (SCA) is a hereditary hemoglobinopathy characterized by the presence of
abnormal hemoglobin S (HbS), leading to the polymerization of red blood cells and the …

Sickle cell disease (SCD) is the most severe monogenic hemoglobinopathy caused by a
single genetic mutation that leads to repeated polymerization and depolymerization of …

Sickle cell disease (SCD) is a monogenetic disease that results in the formation of
hemoglobin S. Due to more rapid oxidation of hemoglobin S due to intracellular heme and …

Background Sickle cell anemia (SCA) is a clinically heterogeneous, monogenic disorder.
Medical care has less‐than‐optimal impact on clinical outcomes in SCA in Africa due to …

Background: The phenotypic expression of sickle cell disease (SCD) is a complex
pathophysiologic condition. However, sickle erythrocytes might be the cause for multiple …