How I treat AL amyloidosis

G Palladini, G Merlini - Blood, The Journal of the American …, 2022 - ashpublications.org
The treatment of patients with systemic light chain (AL) amyloidosis is a challenge to
hematologists. Despite its generally small size, the underlying clone causes a rapidly …

[PDF][PDF] Light chain amyloidosis 2014

ME Gatt - Int J Hematol Disorder, 2014 - Citeseer
AL amyloidosis patients are difficult to diagnose. Patients having multi-organ and particularly
cardiac involvement are considered to have bad prognosis. Early diagnosis is therefore …

New insights and modern treatment of AL amyloidosis

CP Chaulagain, RL Comenzo - Current hematologic malignancy reports, 2013 - Springer
Systemic amyloidosis is a rare disease that is rarely cured. Systemic immunoglobulin light-
chain amyloidosis (AL) is the most common type, usually the result of monoclonal light …

Current status of hematopoietic cell transplantation in the treatment of systemic amyloid light-chain amyloidosis

SO Schönland, P Dreger, T De Witte… - Bone marrow …, 2012 - nature.com
Systemic amyloid light-chain (AL) amyloidosis is a protein conformation disorder caused by
clonal plasma cell dyscrasias. Symptoms result from fibrillar extracellular deposits in various …

Short‐and long‐term outcomes of AL amyloidosis patients admitted into intensive care units

D Guinault, E Canet, A Huart, A Jaccard… - British Journal of …, 2016 - Wiley Online Library
Amyloidosis is a rare and threatening condition that may require intensive care because of
amyloid deposit‐related organ dysfunction or therapy‐related adverse events. Although new …

[HTML][HTML] Treatment patterns and clinical outcomes among patients with newly diagnosed and relapsed/refractory systemic light chain amyloidosis

HM Lin, CV Asche, J Ren, C Yong, H Parameswaran… - Blood, 2016 - Elsevier
OBJECTIVES: The prognosis for light chain amyloidosis (AL) is generally poor, particularly
with cardiac, renal and multi-organ involvement. Treatment options for patients with …

Outcomes and treatments of relapsed AL amyloidosis following stem cell transplant

R Warsame, SM Bang, SK Kumar, MQ Lacy, FK Buadi… - 2012 - ashpublications.org
Abstract 1858 Systemic light chain amyloidosis (AL amyloidosis) is a condition where clonal
plasma cells produce misfolded insoluble immunoglobulin light chains that deposit in …

New and developing therapies for AL amyloidosis

G Zumbo, O Sadeghi-Alavijeh… - Expert Opinion on …, 2017 - Taylor & Francis
Introduction: Systemic light-chain (AL) amyloidosis is an infiltrative disorder associated with
an underlying plasma cells dyscrasia, in which monoclonal immunoglobulin light chains …

The quest for validated treatment endpoints in light chain (AL) amyloidosis: composite criteria for a composite disease

G Palladini, P Milani - Leukemia & Lymphoma, 2021 - Taylor & Francis
Shen and coworkers elegantly validated a composite hematologic and organ response
(CHOR) model in 388 patients with light chain (AL) amyloidosis treated between 2008 and …

Update on the contemporary treatment of light chain amyloidosis including stem cell transplantation

M Abdallah, V Sanchorawala - The American Journal of Medicine, 2022 - Elsevier
The management of immunoglobulin light chain (AL) amyloidosis is complex. Emerging data
have shown promising results for several novel agents. We review the management of AL …