AL amyloidosis: untangling new therapies

S Bal, H Landau - Hematology, 2021 - ashpublications.org
Systemic light chain (AL) amyloidosis is a protein misfolding disorder characterized by the
deposition of abnormal immunoglobulin light chains in fibrillary aggregates, resulting in end …

Management of AL amyloidosis in 2020

G Palladini, P Milani, G Merlini - Blood, The Journal of the …, 2020 - ashpublications.org
In amyloid light chain (AL) amyloidosis, a small B-cell clone, most commonly a plasma cell
clone, produces monoclonal light chains that exert organ toxicity and deposit in tissue in the …

Learning from patients: the interplay between clinical and laboratory research in AL amyloidosis

ME Gatt, M Pick - Hemato, 2021 - mdpi.com
Primary systemic light chain amyloidosis (AL) is a rare monoclonal plasma cell disorder.
Much research has been performed to determine the factors that underly amyloidogenicity …

[PDF][PDF] Treatment of primary systemic amyloidosis (AL): role of intensive and standard therapy

T Sher, SR Hayman, MA Gertz - Clin Adv Hematol …, 2012 - hematologyandoncology.net
Immunoglobulin light-chain (AL) amyloidosis is a clonal plasma cell dyscrasia. Delay in
diagnosis is the major hurdle in improving the outcomes of AL patients. Almost all patients …

Light-chain (AL) amyloidosis: diagnosis and treatment

V Sanchorawala - Clinical Journal of the American Society of …, 2006 - journals.lww.com
Light-chain (AL) amyloidosis is the most common form of systemic amyloidosis and is
associated with an underlying plasma cell dyscrasia. The disease often is difficult to …

[HTML][HTML] Systemic AL Amyloidosis and Precision Medicine

A Rüfer, R Schwotzer - healthbook …, 2021 - onco-hema.healthbooktimes.org
In amyloid light-chain (AL) amyloidosis, a small plasma-cell clone, or less frequently a
mature B-cell clone, produces toxic monoclonal light chains that can be deposited in the …

A second autologous hematopoietic cell transplantation is a safe and effective salvage therapy in select relapsed or refractory AL amyloidosis patients

CR Tan, N Estrada-Merly, H Landau… - Bone marrow …, 2022 - nature.com
Systemic light chain (AL) amyloidosis is a rare plasma cell neoplasm caused by misfolded
protein deposition resulting in organ dysfunction. High-dose melphalan with autologous …

Ten‐year survivors in AL amyloidosis: characteristics and treatment pattern

E Muchtar, MA Gertz, MQ Lacy, RS Go… - British journal of …, 2019 - Wiley Online Library
Improvement in survival in Light chain (AL) amyloidosis has been seen over recent decades,
enabling more patients to achieve long‐term survival. Patients with AL amyloidosis who …

[HTML][HTML] Predictors of Early Relapse Following Initial Therapy for Systemic Immunoglobulin Light Chain Amyloidosis

N Tandon, S Sidana, MA Gertz, A Dispenzieri, MQ Lacy… - Blood, 2016 - Elsevier
Introduction Immunoglobulin light chain amyloidosis (AL Amyloidosis) is a monoclonal
plasma cell proliferative disorder that is characterized by tissue deposits of misfolded …

Diagnostic and treatment strategies for AL amyloidosis in an era of therapeutic innovation

D Dima, S Mazzoni, F Anwer, J Khouri… - JCO Oncology …, 2023 - ascopubs.org
Despite significant progress and improving outcomes in the management of plasma cell
disorders, AL amyloidosis remains diagnostically and therapeutically challenging for …