AL amyloidosis: untangling new therapies
S Bal, H Landau - Hematology, 2021 - ashpublications.org
Systemic light chain (AL) amyloidosis is a protein misfolding disorder characterized by the
deposition of abnormal immunoglobulin light chains in fibrillary aggregates, resulting in end …
deposition of abnormal immunoglobulin light chains in fibrillary aggregates, resulting in end …
Management of AL amyloidosis in 2020
In amyloid light chain (AL) amyloidosis, a small B-cell clone, most commonly a plasma cell
clone, produces monoclonal light chains that exert organ toxicity and deposit in tissue in the …
clone, produces monoclonal light chains that exert organ toxicity and deposit in tissue in the …
Learning from patients: the interplay between clinical and laboratory research in AL amyloidosis
ME Gatt, M Pick - Hemato, 2021 - mdpi.com
Primary systemic light chain amyloidosis (AL) is a rare monoclonal plasma cell disorder.
Much research has been performed to determine the factors that underly amyloidogenicity …
Much research has been performed to determine the factors that underly amyloidogenicity …
[PDF][PDF] Treatment of primary systemic amyloidosis (AL): role of intensive and standard therapy
T Sher, SR Hayman, MA Gertz - Clin Adv Hematol …, 2012 - hematologyandoncology.net
Immunoglobulin light-chain (AL) amyloidosis is a clonal plasma cell dyscrasia. Delay in
diagnosis is the major hurdle in improving the outcomes of AL patients. Almost all patients …
diagnosis is the major hurdle in improving the outcomes of AL patients. Almost all patients …
Light-chain (AL) amyloidosis: diagnosis and treatment
V Sanchorawala - Clinical Journal of the American Society of …, 2006 - journals.lww.com
Light-chain (AL) amyloidosis is the most common form of systemic amyloidosis and is
associated with an underlying plasma cell dyscrasia. The disease often is difficult to …
associated with an underlying plasma cell dyscrasia. The disease often is difficult to …
[HTML][HTML] Systemic AL Amyloidosis and Precision Medicine
A Rüfer, R Schwotzer - healthbook …, 2021 - onco-hema.healthbooktimes.org
In amyloid light-chain (AL) amyloidosis, a small plasma-cell clone, or less frequently a
mature B-cell clone, produces toxic monoclonal light chains that can be deposited in the …
mature B-cell clone, produces toxic monoclonal light chains that can be deposited in the …
A second autologous hematopoietic cell transplantation is a safe and effective salvage therapy in select relapsed or refractory AL amyloidosis patients
CR Tan, N Estrada-Merly, H Landau… - Bone marrow …, 2022 - nature.com
Systemic light chain (AL) amyloidosis is a rare plasma cell neoplasm caused by misfolded
protein deposition resulting in organ dysfunction. High-dose melphalan with autologous …
protein deposition resulting in organ dysfunction. High-dose melphalan with autologous …
Ten‐year survivors in AL amyloidosis: characteristics and treatment pattern
Improvement in survival in Light chain (AL) amyloidosis has been seen over recent decades,
enabling more patients to achieve long‐term survival. Patients with AL amyloidosis who …
enabling more patients to achieve long‐term survival. Patients with AL amyloidosis who …
[HTML][HTML] Predictors of Early Relapse Following Initial Therapy for Systemic Immunoglobulin Light Chain Amyloidosis
Introduction Immunoglobulin light chain amyloidosis (AL Amyloidosis) is a monoclonal
plasma cell proliferative disorder that is characterized by tissue deposits of misfolded …
plasma cell proliferative disorder that is characterized by tissue deposits of misfolded …
Diagnostic and treatment strategies for AL amyloidosis in an era of therapeutic innovation
Despite significant progress and improving outcomes in the management of plasma cell
disorders, AL amyloidosis remains diagnostically and therapeutically challenging for …
disorders, AL amyloidosis remains diagnostically and therapeutically challenging for …