Diagnostic and treatment strategies for AL amyloidosis in an era of therapeutic innovation

D Dima, S Mazzoni, F Anwer, J Khouri… - JCO Oncology …, 2023 - ascopubs.org
Despite significant progress and improving outcomes in the management of plasma cell
disorders, AL amyloidosis remains diagnostically and therapeutically challenging for …

Renal transplantation in light chain amyloidosis: coming out of the cupboard

F Bridoux, P Ronco, J Gillmore… - Nephrology Dialysis …, 2011 - academic.oup.com
A few years ago, such an editorial comment on kidney transplantation in systemic AL
amyloidosis would have been unthinkable. AL amyloidosis is a multisystem disease related …

[HTML][HTML] Healthcare Resource utilization and costs of patients with al amyloidosis: an analysis of hospitalizations in the premier database

TP Quock, E Chang, K Bognar, A D'Souza, MS Broder - Blood, 2021 - Elsevier
METHODS To understand characteristics, healthcare resource utilization, costs, and clinical
outcomes associated with AL amyloidosis for patients treated in US hospitals, this …

Presentation and outcome with second-line treatment in AL amyloidosis previously sensitive to nontransplant therapies

G Palladini, P Milani, A Foli, M Basset… - Blood, The Journal …, 2018 - ashpublications.org
The management of light chain (AL) amyloidosis has improved in recent years thanks to
accurate biomarker-based staging systems and response criteria and availability of novel …

[HTML][HTML] Induction therapy with bortezomib followed by bortezomib-high dose melphalan and stem cell transplantation for light chain amyloidosis: results of a …

V Sanchorawala, D Brauneis, AC Shelton, S Lo… - Biology of Blood and …, 2015 - Elsevier
The depth of hematologic response has been shown to correlate with survival and organ
responses for patients with light chain (AL) amyloidosis. We conducted a prospective trial of …

Clinical trials evaluating potential therapies for light chain (AL) amyloidosis

E Muchtar, MA Gertz - Expert opinion on orphan drugs, 2017 - Taylor & Francis
Introduction: The field of systemic amyloidosis is experiencing major advances in diagnostic
and prognostic methods coupled with a growing availability in treatment options. Areas …

Dose-intensive melphalan with blood stem cell support for the treatment of AL amyloidosis: one-year follow-up in five patients

RL Comenzo, E Vosburgh, RW Simms, P Bergethon… - 1996 - ashpublications.org
The morbidity and lethality of AL amyloidosis is caused by the deposition of lg light chains as
fibrillar amyloid protein in vital organs, disrupting their function, and not by the generally low …

Treatment of Amyloid Light-Chain Amyloidosis

G Buda, P Morfino, A Aimo, AD Wechalekar - … Amyloidosis: Diagnosis and …, 2024 - Springer
Amyloid light-chain amyloidosis (AL) is characterized by deposits of immunoglobulin κ or λ
free light chains (FLCs) produced by clonal bone marrow plasma cells. FLCs transform into …

Real-world treatment patterns, costs, and outcomes in patients with AL amyloidosis: analysis of the Optum EHR and commercial claims databases

A Dispenzieri, J Zonder, J Hoffman, SW Wong… - Amyloid, 2023 - Taylor & Francis
Background This study characterised real-world treatment patterns, clinical outcomes, and
cost-of-illness in patients with light-chain (AL) amyloidosis. Methods Data were extracted …

In search of the most effective therapy for light chain amyloidosis

G Palladini, P Milani, G Merlini - Amyloid, 2022 - Taylor & Francis
We thank Dr. Solomon for his interest in our article on the management of light chain (AL)
amyloidosis [1]. At present, the treatment of AL amyloidosis is aimed at suppressing the …