[HTML][HTML] Recent improvements in survival in light chain amyloidosis and the importance of an early mortality risk score

S Kumar, M Gertz, M Lacy, D Dingli, SR Hayman… - Blood, 2010 - Elsevier
Abstract Abstract 1892 Background: Primary or light chain amyloidosis (AL) is a clonal
plasma cell disorder characterized by a relatively low plasma cell burden and multi-organ …

Light chain (AL) amyloidosis: the journey to diagnosis

KL McCausland, MK White, SD Guthrie… - The Patient-Patient …, 2018 - Springer
Background Light chain (AL) amyloidosis is a rare, complex disease associated with
significant morbidity and mortality. Delays in diagnosis are common and may have …

Current and emerging views and treatments of systemic immunoglobulin light-chain (Al) amyloidosis

RL Comenzo - The Kidney in Plasma Cell Dyscrasias, 2007 - karger.com
Amyloidosis is a disease in which abnormal proteins form toxic intermediates and fibrillar
tissue-deposits that compromise key viscera and lead to early death. In order to treat …

[HTML][HTML] Prospective Phase II Study Using Dexamethasone Induction Therapy and High-Dose Melphalan Chemotherapy Followed by Autologous Stem Cell …

S Schonland, U Hegenbart, A Benner, J Perz… - Blood, 2009 - Elsevier
Abstract Abstract 3401 Poster Board III-289 Introduction: Systemic amyloid light chain
amyloidosis (AL) is a fatal monoclonal plasma cell disorder which leads to depositions of …

Treatment patterns and outcomes in light chain amyloidosis: An institutional registry of amyloidosis report in Argentina

ML Posadas-Martinez, MA Aguirre, E Brulc, MS Saez… - PLoS …, 2022 - journals.plos.org
Light chain (AL) amyloidosis is a form of systemic amyloidosis, causing organ dysfunction,
mainly affecting the heart and kidney. Patient-tailored and risk-adapted decision making is …

[HTML][HTML] Therapeutic strategies for initial treatment of AL amyloidosis: implications of therapy and response on outcome

A Paul, A Dispenzieri, MA Gertz, MQ Lacy, FK Buadi… - Blood, 2013 - Elsevier
Background Treatment of AL amyloidosis (AL) has typically followed the treatment patterns
used in myeloma, but has changed in a disease specific manner during the past few years …

Organ responses after highdose melphalan and stemcell transplantation in AL amyloidosis

R Szalat, S Sarosiek, A Havasi, D Brauneis, JM Sloan… - Leukemia, 2021 - nature.com
AL amyloidosis is the most common systemic amyloidoses. In this disorder, clonal plasma
cells or B cells produce monoclonal immunoglobulin free light chains that misfold …

High-dose melphalan and autologous hematopoietic stem cell transplantation in primary amyloidosis: single-center results

G Charlinski, M Ziarkiewicz, P Boguradzki… - Transplantation …, 2014 - Elsevier
Background Systemic immunoglobulin light-chain amyloidosis (AL) is a plasma cell
dyscrasia resulting in multisystem organ failure and death. Autologous hematopoietic stem …

Impact of time to diagnosis on Mayo stages, treatment outcome, and survival in patients with AL amyloidosis and cardiac involvement

S Oubari, E Naser, M Papathanasiou… - European Journal of …, 2021 - Wiley Online Library
Objective To study the impact of time to diagnosis on cardiac Mayo stages, treatment
outcome, and overall survival. Methods We retrospectively analyzed 77 consecutive patients …

[HTML][HTML] Systemic AL amyloidosis: current approach and future direction

MB Zerdan, L Nasr, F Khalid, S Allam, Y Bouferraa… - Oncotarget, 2023 - ncbi.nlm.nih.gov
Systemic Light chain (AL) amyloidosis is a monoclonal plasma cell proliferative disorder
characterized by deposition of amyloidogenic monoclonal light chain fragments causing …