In the adult mammal, haemopoiesis is restricted to the extravascular compartment of the
bone marrow (BM) where primitive haemopoietic stem cells (HSC) and their clonogenic …

Haemopoiesis occurs in intimate physical association with the stromal elements of the bone
marrow. Current evidence supports the hypothesis that the restriction of primitive …

Current data suggest that interplay between two classes of molecules contributes to the
regulation of hematopoiesis: hematopoietic growth factors, which regulate the survival …

HEMATOPOIESIS IS A complex process in which pluripo-tent stem cells proliferate and
differentiate to generate the full complement of mature blood cells. More than 30 …

Significant progress has been made recently in the understanding of cell adhesion
signaling. Many components of focal adhesion complexes have been identified in fibroblasts …

Abstract Here, Martin Hemler focuses on the emerging field of hematopooetic cell adhesion
to extracellular matrix. Analysis of newly discovered receptor structures involved in cell …

Normal steady-state hematopoiesis takes place in the bone marrow microenvironment.
Soluble factors as well as contact interactions between the hematopoietic cells and the …

The importance of adhesion receptors in haematopoiesis Stem cells are the basic cellular
units responsible for the development of all tissue and organ systems in the body. It …

Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma.
This review examines some adhesion molecules which are expressed in haemopoietic …

The role of the bone marrow microenvironment in promoting proliferation and differentiation
of primitive hematopoietic cells has been well established through the development of long …