An enormous body of literature has accumulated over the past 15 years implicating
apoptosis (programmed cell death) in breast cancer cell death induced by conventional and …

Apoptosis is an integral part of normal mammary gland development, differentiation, and
function. Numerous descriptive and mechanistic studies of programmed cell death pathways …

Defective apoptosis (programmed cell death) represents a major causative factor in the
development and progression of cancer. The ability of tumor cells to evade engagement of …

Background: In the clinical setting, anticancer therapy is routinely administered to stimulate
programmed cell death or “apoptosis.” The goal is to eliminate tumor cells. Whether …

Dysregulation of apoptosis plays a major role in cancer etiology. Cancer cells often contain
genetic abnormalities which allow the cells to survive under conditions that normally would …

Apoptosis plays important roles in the development of the mammary gland, and its
impairment has been speculated to promote breast cancer. In mammary epithelial cells …

A fundamental characteristic of cancer cells is suppression of apoptosis and increased cell
survival. 1, 2 These properties, when combined with deregulated cell proliferation, are the …

Programmed cell death via apoptosis is characteristically disturbed in human cancers. This
facilitates not only tumor formation and progression, but also treatment resistance. Since …

Recent knowledge on apoptosis has made it possible to devise novel approaches, which
exploit this process to treat cancer. In this review, we discuss in detail approaches to induce …

Breast cancer is a principal cause of cancer-related mortality in female worldwide. While
many approved therapies have shown promising outcomes in treating breast cancer …