The induction of apoptosis, a physiological type of cell death, is currently the primary
therapeutic aim of most cancer therapies. As resistance to apoptosis is an early hallmark of …

The role of apoptosis in cancer development and emerging treatment strategies has rapidly
expanded over the past few years. The novel discovery in the apoptotic pathways and their …

Other than patient survival, the most important endpoint in cancer therapy is tumor
regression. To achieve this endpoint, most non-invasive therapeutic modalities, with the …

Abstract Learning Objectives After completing this course, the reader will be able to: List the
multiple cell death pathways that are activated in response to chemotherapeutic agents …

The aim of this Special Issue on the deregulation of cell death in cancer is to bring together
recent perspectives on the relationship between tumorigenesis and programmed cell death …

The omission or repression of cell death has a dual impact on medical oncology. First,
disabling the signal transduction mechanisms leading to cell death and/or suppression of …

Abstract Death ligands (TNF, FasL, TRAIL) and their respective death receptor signaling
pathways can be used to induce tumor cells to undergo apoptosis. Chemotherapeutic drugs …

After more than twenty years of research, the molecular events of apoptotic cell death can be
succinctly stated; different pathways, activated by diverse signals, increase the activity of …

Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

Malignant transformation, tumor progression and resistance to cancer therapy often occur in
the context of disabled cell death signaling. Here we describe the major mechanisms of cell …