Dentate granule neuron apoptosis and glia activation in murine hippocampus induced by trimethyltin exposure

A Fiedorowicz, I Figiel, B Kamińska, M Zaremba, S Wilk… - Brain research, 2001 - Elsevier
We investigated the effect of trimethyltin (TMT), a well-known neurotoxicant, on murine
hippocampal neurons and glial cells. Three days following intraperitoneal (ip) injection of …

Neuronal degeneration and glial cell-responses following trimethyltin intoxication in the rat

S Haga, C Haga, T Aizawa, K Ikeda - Acta neuropathologica, 2002 - Springer
Trimethyltin (TMT) preferentially induces neuronal changes in the hippocampus and
pyriform cortex. In the present study we investigated the time course of microglial and …

Long-term microglial and astroglial activation in the hippocampus of trimethyltin-intoxicated rat: stimulation of NGF and TrkA immunoreactivities in astroglia but not in …

D Koczyk, B Oderfeld-Nowak - International Journal of Developmental …, 2000 - Elsevier
In the present study we investigated the microglial and astroglial response after trimethyltin
(TMT) exposure over a prolonged period of time. Male Wistar rats were given a single dose …

In vivo activation of c-Jun N-terminal kinase signaling cascade prior to granule cell death induced by trimethyltin in the dentate gyrus of mice

K Ogita, Y Nitta, M Watanabe, Y Nakatani… - …, 2004 - Elsevier
The systemic administration of trimethyltin (TMT, 2.8 mg/kg, ip) induced granule cell death in
the mouse dentate gyrus selectively 2 days later. The administration of TMT not only …

Cyclooxygenase-2 and caspase 3 expression in trimethyltin-induced apoptosis in the mouse hippocampus

MC Geloso, A Vercelli, V Corvino, M Repici… - Experimental …, 2002 - Elsevier
The neurotoxicant trimethyltin (TMT) induces massive neuronal loss in vivo in the
hippocampus of rodents, accompanied by behavioral alterations. The present study …

Glia increase degeneration of hippocampal neurons through release of tumor necrosis factor-α

B Viviani, E Corsini, CL Galli, M Marinovich - Toxicology and applied …, 1998 - Elsevier
This study characterizes the role of glial cells in chemically induced neurodegeneration. We
evaluated the effect of trimethyltin, a trisubstituted organotin compound that elicits distinct …

Involvement of microglia–neuron interactions in the tumor necrosis factor‐α release, microglial activation, and neurodegeneration induced by trimethyltin

C Eskes, L Juillerat‐Jeanneret, G Leuba… - Journal of …, 2003 - Wiley Online Library
Trimethyltin (TMT) is a neurotoxicant known to induce early microglial activation. The
present study was undertaken to investigate the role played by these microglial cells in the …

Trimethyltin-induced neurogenesis in the murine hippocampus

GJ Harry, CA McPherson, RN Wine, K Atkinson… - Neurotoxicity …, 2003 - Springer
Neurogenesis continues to occur in the mature rodent brain with one of the most prominent
sources for new neurons being the subgranular layer (SGL) of the dentate gyrus (DG) in the …

Trimethyltin-induced hippocampal degeneration as a tool to investigate neurodegenerative processes

MC Geloso, V Corvino, F Michetti - Neurochemistry international, 2011 - Elsevier
Trimethyltin (TMT), an organotin compound with neurotoxicant effects selectively localised in
the limbic system and especially marked in the hippocampus, is considered a useful tool to …

Two distinct hippocampal astrocyte morphotypes reveal subfield-different fate during neurodegeneration induced by trimethyltin intoxication

M Dragić, M Zarić, N Mitrović, N Nedeljković, I Grković - Neuroscience, 2019 - Elsevier
Astrocytes comprise a heterogenic group of glial cells, which perform homeostatic functions
in the central nervous system. These cells react to all kind of insults by changing the …