A previously unrecognized large fraction of cytotoxic lymphocyte precursors is present in CD4+ human peripheral blood T cells
D Kabelitz, C Brucker, H Wagner, B Fleischer - Cellular immunology, 1989 - Elsevier
We describe a limiting dilution (LD) culture system in which cell sorter-purified CD4+(and
CD8+) peripheral blood T cells are cocultured with irradiated, anti-CD3 mab-producing …
CD8+) peripheral blood T cells are cocultured with irradiated, anti-CD3 mab-producing …
Cytotoxic activities of normal cultured human T cells
JM Alvarez, MO de Landazuri, GD Bonnard… - The Journal of …, 1978 - journals.aai.org
Normal human T cells grown in continued cultures in medium containing conditioned
medium (CM) from PHA-stimulated lymphocytes were studied for their ability to manifest …
medium (CM) from PHA-stimulated lymphocytes were studied for their ability to manifest …
Human Cytotoxic T Lymphocytes: I. Limiting‐Dilution Analysis of Alloreactive Cytotoxic T‐Lymphocyte Precursor Frequencies
D Kabelitz, WR Herzog, B Zanker… - Scandinavian journal of …, 1985 - Wiley Online Library
A limiting‐dilution system was established to measure the frequency of alloreactive cytotoxic
T‐lymphocyte precursors (CTL‐p) in human peripheral blood T cells. Culture medium …
T‐lymphocyte precursors (CTL‐p) in human peripheral blood T cells. Culture medium …
Human cytotoxic lymphocytes. V. Frequency and specificity of gamma delta+ cytotoxic lymphocyte precursors activated by allogeneic or autologous stimulator cells.
D Kabelitz, A Bender, S Schondelmaier… - … (Baltimore, Md.: 1950 …, 1990 - journals.aai.org
We have investigated the frequency and specificity of gamma delta+ cytotoxic lymphocyte
precursors (CLP) under limiting dilution culture conditions. E rosette separated total T cells …
precursors (CLP) under limiting dilution culture conditions. E rosette separated total T cells …
Heterogeneous mechanisms of human cytotoxic T lymphocyte generation. I. Differential helper cell requirement for the generation of cytotoxic effector cells from CD8+ …
HZ Bass, N Yamashita, LT Clement - Journal of immunology …, 1992 - journals.aai.org
The subpopulations of CD8+ T cells defined by CD45RA Ag expression have been
hypothesized to represent cells varying in their relative maturation along a common …
hypothesized to represent cells varying in their relative maturation along a common …
Semi-automated limit-dilution assay and clonal expansion of all T-cell precursors of cytotoxic lymphocytes
A Wilson, WF Chen, R Scollay, K Shortman - Journal of Immunological …, 1982 - Elsevier
A limit-dilution microculture system is described, where almost all precursor T cells of the
cytotoxic lineage (CTL-p) develop into extended clones of cytotoxic T cells (CTL), which are …
cytotoxic lineage (CTL-p) develop into extended clones of cytotoxic T cells (CTL), which are …
Alloreactive cytotoxic T cells can develop and function in mice lacking both CD4 and CD8
MW Schilham, WP Fung‐Leung… - European journal of …, 1993 - Wiley Online Library
Using the technique of homologous recombination in embryonic stem cells, a mouse strain
without functional CD4 and CD8 genes has been generated. Surprisingly, these mice …
without functional CD4 and CD8 genes has been generated. Surprisingly, these mice …
Clonal activation of cytotoxic lymphocyte precursors by monoclonal anti-CD3 antibody: analysis of feeder cell requirements
C Brucker, J Reimann, H Wagner, D Kabelitz - Immunology letters, 1987 - Elsevier
Activation of cytotoxic lymphocyte precursors (CLP) by the mitogenic monoclonal anti-CD3
antibody OKT3 was studied under limiting dilution (LD) culture conditions. One out of 2–6 E …
antibody OKT3 was studied under limiting dilution (LD) culture conditions. One out of 2–6 E …
Cytokine-induced differentiation of precursor mouse CD8+ T cells into cytotoxic CD8+ T cells secreting Th1 or Th2 cytokines
S Sad, R Marcotte, TR Mosmann - Immunity, 1995 - cell.com
Alloantigen-stimulated CD8+ mouse spleen cells, either spontaneously or in the presence of
IL-12 or IFNy plus anti-IL-4, differentiate into CD8+ T cells secreting a Thl-like cytokine …
IL-12 or IFNy plus anti-IL-4, differentiate into CD8+ T cells secreting a Thl-like cytokine …
Differences in surface phenotype and mechanism of action between alloantigen-specific CD8+ cytotoxic and suppressor T cell clones.
J Koide, EG Engleman - Journal of immunology (Baltimore, Md …, 1990 - journals.aai.org
We have previously demonstrated that fresh CD8+ T cells proliferate in response to
autologous, alloantigen-primed CD4+ T cells, and differentiate into Ts cells, which inhibit the …
autologous, alloantigen-primed CD4+ T cells, and differentiate into Ts cells, which inhibit the …