Chemerin-9-induced contraction was enhanced through the upregulation of smooth muscle chemokine-like receptor 1 in isolated pulmonary artery of pulmonary …

A Omori, M Goshima, C Kakuda, T Kodama… - … -European Journal of …, 2020 - Springer
Chemerin is an adipocytokine having cardiovascular effects. Chemokine-like receptor 1
(CMKLR1) and chemokine (CC motif) receptor-like 2 (CCRL2) are chemerin receptors …

Chemerin added to endothelin-1 promotes rat pulmonary artery smooth muscle cell proliferation and migration

A Hanthazi, P Jespers, G Vegh, C Dubois… - Frontiers in …, 2020 - frontiersin.org
Background While chemerin has been shown to increase proliferation and migration of
systemic vascular smooth muscle cells (SMCs) contributing therefore to the development of …

Chemerin Regulates the Proliferation and Migration of Pulmonary Arterial Smooth Muscle Cells via the ERK1/2 Signaling Pathway

L Peng, Y Chen, Y Li, P Feng, Y Zheng… - Frontiers in …, 2022 - frontiersin.org
Pulmonary arterial hypertension (PAH) is an incurable disease with high mortality. Chemerin
has been found to be associated with pulmonary hypertension (PH). However, the specific …

Chemerin connects fat to arterial contraction

SW Watts, AM Dorrance, ME Penfold… - … , and vascular biology, 2013 - Am Heart Assoc
Objective—Obesity and hypertension are comorbid in epidemic proportion, yet their
biological connection is largely a mystery. The peptide chemerin is a candidate for …

Chemerin Elicits Potent Constrictor Actions via Chemokine‐Like Receptor 1 (CMKLR 1), not G‐Protein‐Coupled Receptor 1 (GPR 1), in Human and Rat Vasculature

AJ Kennedy, P Yang, C Read, RE Kuc… - Journal of the …, 2016 - Am Heart Assoc
Background Circulating levels of chemerin are significantly higher in hypertensive patients
and positively correlate with blood pressure. Chemerin activates chemokine‐like receptor 1 …

Chemerin-9 stimulates migration in rat cardiac fibroblasts in vitro

A Yamamoto, A Sagara, K Otani, M Okada… - European Journal of …, 2021 - Elsevier
Since chemerin is an adipocytokine whose concentration in blood increases in the subjects
with various cardiac diseases, chemerin may be involved in pathogenesis of cardiac …

Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis

J Kaur, R Adya, BK Tan, J Chen… - … and biophysical research …, 2010 - Elsevier
Chemerin acting via its distinct G protein-coupled receptor CMKLR1 (ChemR23), is a novel
adipokine, circulating levels of which are raised in inflammatory states. Chemerin shows …

[HTML][HTML] Chemerin stimulates aortic smooth muscle cell proliferation and migration via activation of autophagy in VSMCs of metabolic hypertension rats

J Wen, J Wang, L Guo, W Cai, Y Wu… - American journal of …, 2019 - ncbi.nlm.nih.gov
Vascular remodeling is a characteristic pathogenesis of hypertension and a main cause of
abnormal construction and function of organs because of hypertension. Chemerin is a new …

Chemerin promotes the proliferation and migration of vascular smooth muscle and increases mouse blood pressure

H Kunimoto, K Kazama, M Takai… - American Journal …, 2015 - journals.physiology.org
Blood chemerin concentration shows positive correlation not only with body mass index and
serum triglyceride level but also with systolic blood pressure. While it seems likely that …

Chemerin influences endothelin-and serotonin-induced pulmonary artery vasoconstriction in rats

A Hanthazi, P Jespers, G Vegh, GN Degroot… - Life sciences, 2019 - Elsevier
Aims Chemerin has been recently identified as a vasoactive adipokine implicated in blood
pressure regulation. In this context, we evaluated whether chemerin could influence …