Objective To identify the top brain regions affected by MS-specific atrophy (ie, atrophy in
excess of normal aging) and to test whether normal aging and MS-specific atrophy increase …

With high-resolution quantitative magnetic resonance imaging (MRI) techniques, it is
possible to examine alterations in brain anatomy in vivo and to identify regions affected in …

Objective: To establish the progression of brain atrophy rates in patients with a known date
of onset of Alzheimer disease (AD). Methods: Each of 18 subjects had two high-resolution …

Important risk factors for Alzheimer's disease (AD) are ageing and the Apolipoprotein E
(APOE) ε4 allele, with female APOE ε4 carriers having the greatest risk. In this study we …

Objective The objective of this study is to demonstrate the assessment of hippocampal
atrophy within a standard brain atlas for persons with age-associated memory impairment …

Objective: To evaluate the longitudinal influence of family history (FH) of Alzheimer disease
(AD) and apolipoprotein E ϵ4 allele (APOE 4) on brain atrophy and cognitive decline over 4 …

To examine the biological basis of subjective memory impairment (SMI), defined as the
feeling of memory worsening with normal memory performance, we measured the volume of …

Objective: To test the hypothesis that MRI-based measurements of hippocampal volume are
related to the risk of future conversion to Alzheimer's disease (AD) in older patients with a …

Purpose To examine the influence of apoliprotein E ε4 allele (APOE 4) carrier status on
disease progression by evaluating the rate of regional gray matter (GM) volume loss and …

Introduction This review aimed to produce hippocampal atrophy rate estimates from healthy
ageing studies as well as control samples from observational studies across the adult …