Melatonin, an indoleamine derived from tryptophan and produced in the pineal gland and
other tissues [1, 2] is a potent antioxidant and inflammatory agent [1]. Specifically, the …

Over three centuries ago, the French philosopher René Descartes described the pineal
gland as “the seat of the soul.” However, it was not until the late 1950s that the chemical …

Melatonin is a highly evolutionary conserved endogenous molecule that is mainly produced
by the pineal gland, but also by other nonendocrine organs, of most mammals including …

Pulmonary arterial hypertension of newborns (PAHN) constitutes a critical condition
involving both severe cardiac remodeling and right ventricle dysfunction. One main cause of …

Oxidative stress plays a key role in the pathogenesis of aging and many metabolic diseases;
therefore, an effective antioxidant therapy would be of great importance in these …

Melatonin is a neurohormone produced by the pineal gland that regulates sleep and
circadian functions. Melatonin also regulates inflammatory and immune processes acting as …

Melatonin is known for its radical scavenger activity, which is related to its ability to protect
cells from different kinds of oxidative stress. Oxidative stress has been implicated in the …

Melatonin was found to be a potent free radical scavenger in 1993. Since then over 800
publications have directly or indirectly confirmed this observation. Melatonin scavenges a …

Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

Melatonin is an endogenous hormone derived from tryptophan that is mainly released from
the pineal gland in the dark. Melatonin regulates many biological functions such as sleep …