Interactions between host and pathogen determine the development, progression and
outcomes of disease. Medicine benefits from better descriptions of these interactions …

Microbes are the most prevalent form of life yet also the least well-understood in terms of
their diversity. Due to a greater appreciation of their role in modulating host physiology …

Cellular heterogeneity plays a pivotal role in tissue homeostasis and the disease
development of multicellular organisms. To deconstruct the heterogeneity, a multitude of …

The majority of COVID-19 patients experience mild to moderate disease course and recover
within a few weeks. An increasing number of studies characterized the long-term changes in …

With the success of the Human Genome Project, large-scale systemic projects became a
reality that enabled rapid development of the systems biology field. Systems biology …

Single-cell genomics provide researchers with tools to assess host-pathogen interactions at
a resolution previously inaccessible. Transcriptome analysis, epigenome analysis, and …

Macrophages represent a major immune cell type in tumor microenvironments, they exist in
multiple functional states and are of a strong interest for therapeutic reprogramming. While …

The aim of this project was to advance single-cell RNA-Seq methods toward the
establishment of a platform that may be used to simultaneously interrogate the gene …

Abstract Analysis of human blood immune cells provides insights into the coordinated
response to viral infections such as severe acute respiratory syndrome coronavirus 2, which …

Background: A growing body of evidence has indicated impaired function or compositional
changes of monocytes in inflammatory disorders, such as acute respiratory syndrome and …