Antifungal Susceptibility of Candida Biofilms: Unique Efficacy of Amphotericin B Lipid Formulations and Echinocandins

DM Kuhn, T George, J Chandra… - Antimicrobial agents …, 2002 - Am Soc Microbiol
Biofilms, likely the predominant mode of device-related microbial infection, exhibit resistance
to antimicrobial agents. Evidence suggests that Candida biofilms have dramatically reduced …

Candida biofilm resistance

PK Mukherjee, J Chandra - Drug resistance updates, 2004 - Elsevier
Device-related infections in most nosocomial diseases can be traced to the formation of
biofilms (microbial communities encased within polysaccharide-rich extracellular matrix) by …

Candida biofilms: antifungal resistance and emerging therapeutic options.

DM Kuhn, MA Ghannoum - Current opinion in investigational drugs …, 2004 - europepmc.org
Intravascular catheter infections are a major cause of morbidity and mortality in hospitalized
patients, accounting for the majority of the 200,000 nosocomial bloodstream infections …

Comparison of Biofilms Formed by Candidaalbicans and Candidaparapsilosis on Bioprosthetic Surfaces

DM Kuhn, J Chandra, PK Mukherjee… - Infection and …, 2002 - Am Soc Microbiol
Little is known about fungal biofilms, which may cause infection and antibiotic resistance. In
this study, biofilm formation by different Candida species, particularly Candida albicans and …

Biofilm Formation and Effect of Caspofungin on Biofilm Structure of Candida Species Bloodstream Isolates

JAG Ferreira, JH Carr, CEF Starling… - Antimicrobial agents …, 2009 - Am Soc Microbiol
Candida biofilms are microbial communities, embedded in a polymeric matrix, growing
attached to a surface, and are highly recalcitrant to antimicrobial therapy. These biofilms …

[HTML][HTML] Antifungal drug-resistance mechanisms in Candida biofilms

J Kaur, CJ Nobile - Current opinion in microbiology, 2023 - Elsevier
Highlights•Few classes of antifungal drugs currently exist to treat fungal infections.•Infections
caused by Candida biofilms can be resistant to known antifungal drugs.•Growth in the …

Candida Biofilms: Development, Architecture, and Resistance

J Chandra, PK Mukherjee - Microbial Biofilms, 2015 - Wiley Online Library
The use of indwelling devices in current therapeutic practice is associated with hospital‐
acquired bloodstream and deep tissue infections (1). Transplantation medical procedures …

Species-specific and drug-specific differences in susceptibility of Candida biofilms to echinocandins: characterization of less common bloodstream isolates

M Simitsopoulou, P Peshkova, E Tasina… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Candida species other than Candida albicans are increasingly recognized as causes of
biofilm-associated infections. This is a comprehensive study that compared the in vitro …

Antifungal susceptibility of Candida albicans in biofilms

S Tobudic, C Kratzer, A Lassnigg, E Presterl - Mycoses, 2012 - Wiley Online Library
Candida albicans are the most common fungi associated with biofilm‐related infections.
Biofilms are defined as microbial communities encased in a matrix of extracellular polymeric …

[HTML][HTML] Fungal biofilms and drug resistance

MA Jabra-Rizk, WA Falkler… - Emerging infectious …, 2004 - ncbi.nlm.nih.gov
Candida species, including the novel opportunistic pathogen Candida dubliniensis, are now
emerging as major agents of nosocomial infections. Many such manifestations of infections …